AIMC Topic: Heme

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Graphene-based FETs for advanced biocatalytic profiling: investigating heme peroxidase activity with machine learning insights.

Mikrochimica acta Mar 3, 2025
Graphene-based field-effect transistors (GFETs) are rapidly gaining recognition as powerful tools for biochemical analysis due to their exceptional sensitivity and specificity. In this study, we utilize a GFET system to explore the peroxidase-based b...
Machine Learning Hydrogen Peroxide Heme Graphite Transistors, Electronic Biocatalysis Horseradish Peroxidase
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Machine Learning Predictability of Clinical Next Generation Sequencing for Hematologic Malignancies to Guide High-Value Precision Medicine.

AMIA ... Annual Symposium proceedings. AMIA Symposium Feb 21, 2022
Advancing diagnostic testing capabilities such as clinical next generation sequencing methods offer the potential to diagnose, risk stratify, and guide specialized treatment, but must be balanced against the escalating costs of healthcare to identify...
Humans Machine Learning Precision Medicine Hematologic Neoplasms Mutation Heme High-Throughput Nucleotide Sequencing
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HEMEsPred: Structure-Based Ligand-Specific Heme Binding Residues Prediction by Using Fast-Adaptive Ensemble Learning Scheme.

IEEE/ACM transactions on computational biology and bioinformatics Oct 4, 2016
Heme is an essential biomolecule that widely exists in numerous extant organisms. Accurately identifying heme binding residues (HEMEs) is of great importance in disease progression and drug development. In this study, a novel predictor named HEMEsPre...
Machine Learning Software Algorithms Protein Binding Computational Biology Databases, Protein Models, Molecular Heme Binding Sites Protein Structure, Secondary
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Integrating Bulk and Single-Cell Transcriptomics with Machine Learning Reveals a Heme Metabolism-Based Panel for Lung Adenocarcinoma Chemotherapy Resistance.

International journal of molecular sciences May 14, 2025
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with heme metabolism playing a critical role in tumor progression and treatment resistance. This study investigates the clinical implications of heme metabolism in LUAD, focus...
Humans Machine Learning Prognosis Female Antineoplastic Agents Gene Expression Profiling Transcriptome Cell Line, Tumor Single-Cell Analysis Lung Neoplasms Gene Expression Regulation, Neoplastic Ferroptosis Cisplatin Heme Drug Resistance, Neoplasm Adenocarcinoma of Lung Multidrug Resistance-Associated Proteins Multidrug Resistance-Associated Protein 2
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