AIMC Topic: Multidrug Resistance-Associated Protein 2

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Personalizing cancer therapy: the role of pharmacogenetics in overcoming drug resistance and toxicity.

Molecular biology reports Aug 2, 2025
Cancer pharmacogenetics has become a cornerstone of precision oncology. It offers the potential to optimize therapeutic outcomes by tailoring treatments to individual genetic profiles. This review explores the central role of pharmacogenomics in addr...
Neoplasms Antineoplastic Agents Precision Medicine Biomarkers, Tumor ATP-Binding Cassette Transporters Multidrug Resistance-Associated Protein 2 Pharmacogenetics Drug Resistance, Neoplasm Humans
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Integrating Bulk and Single-Cell Transcriptomics with Machine Learning Reveals a Heme Metabolism-Based Panel for Lung Adenocarcinoma Chemotherapy Resistance.

International journal of molecular sciences May 14, 2025
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with heme metabolism playing a critical role in tumor progression and treatment resistance. This study investigates the clinical implications of heme metabolism in LUAD, focus...
Transcriptome Cell Line, Tumor Antineoplastic Agents Gene Expression Profiling Gene Expression Regulation, Neoplastic Ferroptosis Single-Cell Analysis Lung Neoplasms Humans Machine Learning Prognosis Female Heme Drug Resistance, Neoplasm Cisplatin Multidrug Resistance-Associated Protein 2 Adenocarcinoma of Lung Multidrug Resistance-Associated Proteins
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Multidrug Resistance-Associated Protein 2 Cytochrome P-450 CYP1A1 Multidrug Resistance-Associated Proteins Humans Young Adult Neural Networks, Computer Adult Female Polymorphism, Single Nucleotide Polymorphism, Genetic Half-Life Predictive Value of Tests Middle Aged Deferasirox Drug Compounding Male Adolescent Area Under Curve Cross-Over Studies Iron Chelating Agents Healthy Volunteers Glucuronosyltransferase Asian People
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Predicting Inhibitors for Multidrug Resistance Associated Protein-2 Transporter by Machine Learning Approach.

Combinatorial chemistry & high throughput screening Jan 1, 2018
BACKGROUND: The efflux transporter multidrug resistance associated protein-2 belongs to ATP-binding cassette superfamily which plays an important role in multidrug resistance and drugdrug interactions. Efflux transporters are considered to be importa...
Support Vector Machine Algorithms Machine Learning Multidrug Resistance-Associated Protein 2 Quantitative Structure-Activity Relationship Multidrug Resistance-Associated Proteins Drug Discovery Molecular Structure Databases, Pharmaceutical
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