AIMC Topic: Multidrug Resistance-Associated Protein 2

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Integrating Bulk and Single-Cell Transcriptomics with Machine Learning Reveals a Heme Metabolism-Based Panel for Lung Adenocarcinoma Chemotherapy Resistance.

International journal of molecular sciences May 14, 2025
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with heme metabolism playing a critical role in tumor progression and treatment resistance. This study investigates the clinical implications of heme metabolism in LUAD, focus...
Humans Machine Learning Female Antineoplastic Agents Prognosis Cisplatin Heme Ferroptosis Multidrug Resistance-Associated Proteins Multidrug Resistance-Associated Protein 2 Adenocarcinoma of Lung Drug Resistance, Neoplasm Single-Cell Analysis Transcriptome Gene Expression Profiling Cell Line, Tumor Lung Neoplasms Gene Expression Regulation, Neoplastic
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Cytochrome P-450 CYP1A1 Glucuronosyltransferase Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins Middle Aged Deferasirox Polymorphism, Single Nucleotide Iron Chelating Agents Adolescent Polymorphism, Genetic Adult Male Young Adult Healthy Volunteers Cross-Over Studies Drug Compounding Area Under Curve Half-Life Neural Networks, Computer Asian People Predictive Value of Tests Female Humans
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Predicting Inhibitors for Multidrug Resistance Associated Protein-2 Transporter by Machine Learning Approach.

Combinatorial chemistry & high throughput screening Jan 1, 2018
BACKGROUND: The efflux transporter multidrug resistance associated protein-2 belongs to ATP-binding cassette superfamily which plays an important role in multidrug resistance and drugdrug interactions. Efflux transporters are considered to be importa...
Multidrug Resistance-Associated Proteins Support Vector Machine Multidrug Resistance-Associated Protein 2 Algorithms Databases, Pharmaceutical Drug Discovery Quantitative Structure-Activity Relationship Machine Learning Molecular Structure
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