AIMC Topic: Humans

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Towards automatic US-MR fetal brain image registration with learning-based methods.

NeuroImage
Fetal brain imaging is essential for prenatal care, with ultrasound (US) and magnetic resonance imaging (MRI) providing complementary strengths. While MRI has superior soft tissue contrast, US offers portable and inexpensive screening of neurological...

Identification of Novel Fourth-Generation Allosteric Inhibitors Targeting Inactive State of EGFR T790M/L858R/C797S and T790M/L858R Mutations: A Combined Machine Learning and Molecular Dynamics Approach.

The journal of physical chemistry. B
Targeted therapy with an allosteric inhibitor (AIs) is an important area of research in patients with epidermal growth factor receptor (EGFR) mutations. Current treatment of nonsmall cell lung cancer patients with EGFR mutations using orthosteric inh...

Multitask Deep Learning Models of Combined Industrial Absorption, Distribution, Metabolism, and Excretion Datasets to Improve Generalization.

Molecular pharmaceutics
The optimization of absorption, distribution, metabolism, and excretion (ADME) profiles of compounds is critical to the drug discovery process. As such, machine learning (ML) models for ADME are widely used for prioritizing the design and synthesis o...

SWAPS: A Modular Deep-Learning Empowered Peptide Identity Propagation Framework Beyond Match-Between-Run.

Journal of proteome research
Mass spectrometry (MS)-based proteomics relies heavily on MS/MS (MS2) data, which do not fully exploit the available MS1 information. Traditional peptide identity propagation (PIP) methods, such as match-between-runs (MBR), are limited to similar run...

Advance signal processing and machine learning approach for analysis and classification of knee osteoarthritis vibroarthrographic signals.

Medical engineering & physics
Osteoarthritis is a common cause of disability among elderly significantly affecting their quality of life due to pain and functional limitations. This study proposes a novel, non-invasive, and cost-effective diagnostic technique using vibroarthrogra...

Outcomes of lateral femoral cutaneous nerve decompression surgery in meralgia paraesthetica: assessment of pain, sensory deficits, and quality of life.

International orthopaedics
PURPOSE: Meralgia paraesthetica (MP) is a rare neuropathy of the lateral femoral cutaneous nerve (LFCN), characterized by thigh pain, paraesthesia, or sensory loss. When conservative treatments fail, surgical interventions such as neurolysis or neure...

Structure of activity in multiregion recurrent neural networks.

Proceedings of the National Academy of Sciences of the United States of America
Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its origins i...

The Application of Machine Learning Models to Predict Stillbirths.

Medicina (Kaunas, Lithuania)
: This study aims to evaluate the predictive value of comprehensive data obtained in obstetric clinics for the detection of stillbirth and the predictive ability set of machine learning models for stillbirth. : The study retrospectively included all ...