AIMC Topic: Humans

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AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery.

Nature communications
Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond COVID-19 is impeded by the absence of LNPs tailored for diverse cell types. In this ...

Machine-learning-assisted high-throughput identification of potent and stable neutralizing antibodies against all four dengue virus serotypes.

Scientific reports
Several computational methods have been developed to identify neutralizing antibodies (NAbs) covering four dengue virus serotypes (DENV-1 to DENV-4); however, limitations of the dataset and the resulting performance remain. Here, we developed a new c...

Emergence and reconfiguration of modular structure for artificial neural networks during continual familiarity detection.

Science advances
Advances in artificial intelligence enable neural networks to learn a wide variety of tasks, yet our understanding of the learning dynamics of these networks remains limited. Here, we study the temporal dynamics during learning of Hebbian feedforward...

Deep learning for intracranial aneurysm segmentation using CT angiography.

Physics in medicine and biology
This study aimed to employ a two-stage deep learning method to accurately detect small aneurysms (4-10 mm in size) in computed tomography angiography images.This study included 956 patients from 6 hospitals and a public dataset obtained with 6 CT sca...

A deep learning-based method for the detection and segmentation of breast masses in ultrasound images.

Physics in medicine and biology
Automated detection and segmentation of breast masses in ultrasound images are critical for breast cancer diagnosis, but remain challenging due to limited image quality and complex breast tissues. This study aims to develop a deep learning-based meth...

Pitfalls in Developing Machine Learning Models for Predicting Cardiovascular Diseases: Challenge and Solutions.

Journal of medical Internet research
In recent years, there has been explosive development in artificial intelligence (AI), which has been widely applied in the health care field. As a typical AI technology, machine learning models have emerged with great potential in predicting cardiov...

COVID-19 prevention and control effect of non-pharmaceutical interventions-fuzzy-sets qualitative comparative analysis based on 69 countries in the world.

Frontiers in public health
INTRODUCTION: Coronavirus disease 2019 occurred unexpectedly in late December 2019, it was difficult to immediately develop an effective vaccine or propose targeted medical interventions in the early stages of the outbreak. At this point, non-pharmac...

Methodological evaluation of systematic reviews based on the use of artificial intelligence systems in chest radiography.

Radiologia
INTRODUCTION: In recent years, systems that use artificial intelligence (AI) in medical imaging have been developed, such as the interpretation of chest X-ray to rule out pathology. This has produced an increase in systematic reviews (SR) published o...