AIMC Topic: Humans

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Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Parkinson's disease (PD) is a complex neurodegenerative disorder with an unclear etiology. Despite significant research efforts, developing disease-modifying treatments for PD remains a major unmet medical need. Notably, drug repositioning is becomin...

eDeeplepsy: An artificial neural framework to reveal different brain states in children with epileptic spasms.

Epilepsy & behavior : E&B
OBJECTIVE: Despite advances, analysis and interpretation of EEG still essentially rely on visual inspection by a super-specialized physician. Considering the vast amount of data that composes the EEG, much of the detail inevitably escapes ordinary hu...

Leveraging Artificial Intelligence for Expediting Implementation Efforts.

Creative nursing
Expedited implementation of evidence into practice and policymaking is critical to ensure the delivery of effective care and improve health-care outcomes. Implementation science deals with the designing of methods and strategies for increasing and fa...

Predictive Modelling in pharmacokinetics: from in-silico simulations to personalized medicine.

Expert opinion on drug metabolism & toxicology
INTRODUCTION: Pharmacokinetic parameters assessment is a critical aspect of drug discovery and development, yet challenges persist due to limited training data. Despite advancements in machine learning and in-silico predictions, scarcity of data hamp...

Contributing Components of Metabolic Energy Models to Metabolic Cost Estimations in Gait.

IEEE transactions on bio-medical engineering
OBJECTIVE: As metabolic cost is a primary factor influencing humans' gait, we want to deepen our understanding of metabolic energy expenditure models. Therefore, this paper identifies the parameters and input variables, such as muscle or joint states...

Current safeguards, risk mitigation, and transparency measures of large language models against the generation of health disinformation: repeated cross sectional analysis.

BMJ (Clinical research ed.)
OBJECTIVES: To evaluate the effectiveness of safeguards to prevent large language models (LLMs) from being misused to generate health disinformation, and to evaluate the transparency of artificial intelligence (AI) developers regarding their risk mit...

Estimating human joint moments unifies exoskeleton control, reducing user effort.

Science robotics
Robotic lower-limb exoskeletons can augment human mobility, but current systems require extensive, context-specific considerations, limiting their real-world viability. Here, we present a unified exoskeleton control framework that autonomously adapts...

Modified Retzius-sparing robot-assisted radical prostatectomy for cases with anterior tumor: a propensity score-matched analysis.

World journal of urology
OBJECTIVE: To compare the outcomes between a modified Retzius-sparing robot-assisted radical prostatectomy (mRS-RARP) technique and conventional robot-assisted radical prostatectomy (Con-RARP) technique for cases with anterior prostate cancer (PCa), ...