AIMC Topic: Kinetics

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Using Steady-State Kinetics to Quantitate Substrate Selectivity and Specificity: A Case Study with Two Human Transaminases.

Molecules (Basel, Switzerland)
We examined the ability of two human cytosolic transaminases, aspartate aminotransferase (GOT1) and alanine aminotransferase (GPT), to transform their preferred substrates whilst discriminating against similar metabolites. This offers an opportunity ...

Pyrolytic characteristics of fine materials from municipal solid waste using TG-FTIR, Py-GC/MS, and deep learning approach: Kinetics, thermodynamics, and gaseous products distribution.

Chemosphere
Fine materials (FM) from municipal solid waste (MSW) classification require disposal, and pyrolysis is a feasible method for the treatments. Hence, the behavior, kinetics, and products of FM pyrolysis were investigated in this study. A deep learning ...

Machine Learning-Based Estimation of Ground Reaction Forces and Knee Joint Kinetics from Inertial Sensors While Performing a Vertical Drop Jump.

Sensors (Basel, Switzerland)
Nowadays, the use of wearable inertial-based systems together with machine learning methods opens new pathways to assess athletes' performance. In this paper, we developed a neural network-based approach for the estimation of the Ground Reaction Forc...

A transfer learning approach for predictive modeling of bioprocesses using small data.

Biotechnology and bioengineering
Predictive modeling of new biochemical systems with small data is a great challenge. To fill this gap, transfer learning, a subdomain of machine learning that serves to transfer knowledge from a generalized model to a more domain-specific model, prov...

A Fast Intrusion Detection Method for High-Speed Railway Clearance Based on Low-Cost Embedded GPUs.

Sensors (Basel, Switzerland)
The efficiency and the effectiveness of railway intrusion detection are crucial to the safety of railway transportation. Most current methods of railway intrusion detection or obstacle detection are inappropriate for large-scale applications due to t...

Deep learning allows genome-scale prediction of Michaelis constants from structural features.

PLoS biology
The Michaelis constant KM describes the affinity of an enzyme for a specific substrate and is a central parameter in studies of enzyme kinetics and cellular physiology. As measurements of KM are often difficult and time-consuming, experimental estima...

Smart Bioinspired Actuators: Crawling, Linear, and Bending Motions through a Multilayer Design.

ACS applied materials & interfaces
To fulfill the insatiable demand for wearable technologies, ionic electroactive polymer actuators have been entrenched as promising candidates that can convert low-input-voltage energy into high mechanical throughput. However, a ubiquitous trilayer d...

DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels.

eLife
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few ...

A strategy for mapping biophysical to abstract neuronal network models applied to primary visual cortex.

PLoS computational biology
A fundamental challenge for the theoretical study of neuronal networks is to make the link between complex biophysical models based directly on experimental data, to progressively simpler mathematical models that allow the derivation of general opera...