AIMC Topic: Knowledge Bases

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An updated, computable MEDication-Indication resource for biomedical research.

Scientific reports Sep 23, 2021
The MEDication-Indication (MEDI) knowledgebase has been utilized in research with electronic health records (EHRs) since its publication in 2013. To account for new drugs and terminology updates, we rebuilt MEDI to overhaul the knowledgebase for mode...
Humans Electronic Health Records Biomedical Research Drug Prescriptions Natural Language Processing Knowledge Bases
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A Knowledge Graph Entity Disambiguation Method Based on Entity-Relationship Embedding and Graph Structure Embedding.

Computational intelligence and neuroscience Sep 23, 2021
The purpose of knowledge graph entity disambiguation is to match the ambiguous entities to the corresponding entities in the knowledge graph. Current entity ambiguity elimination methods usually use the context information of the entity and its attri...
Semantics Pattern Recognition, Automated Neural Networks, Computer Knowledge Knowledge Bases
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Genetic dissection of complex traits using hierarchical biological knowledge.

PLoS computational biology Sep 17, 2021
Despite the growing constellation of genetic loci linked to common traits, these loci have yet to account for most heritable variation, and most act through poorly understood mechanisms. Recent machine learning (ML) systems have used hierarchical bio...
Neural Networks, Computer Machine Learning Saccharomyces cerevisiae Gene Ontology Hydroxyurea Glycine Knowledge Bases Nucleotidyltransferases Multifactorial Inheritance Models, Genetic Benomyl Metabolic Networks and Pathways Chromosome Mapping Mutation Glucose Polymorphism, Single Nucleotide Phenotype Computational Biology Copper Genome-Wide Association Study Systems Biology
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Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms.

Frontiers in immunology Sep 7, 2021
RNA vaccines represent a milestone in the history of vaccinology. They provide several advantages over more traditional approaches to vaccine development, showing strong immunogenicity and an overall favorable safety profile. While preclinical testin...
Knowledge Bases Humans Data Mining Animals Computer Graphics Vaccine Development Models, Immunological Natural Language Processing Systems Biology Translational Research, Biomedical mRNA Vaccines
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The Enzyme Portal: an integrative tool for enzyme information and analysis.

The FEBS journal Sep 3, 2021
Enzymes play essential roles in all life processes and are used extensively in the biomedical and biotechnological fields. However, enzyme-related information is spread across multiple resources making its retrieval time-consuming. In response to thi...
Knowledge Bases Enzymes
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Catalyzing Knowledge-Driven Discovery in Environmental Health Sciences through a Community-Driven Harmonized Language.

International journal of environmental research and public health Aug 26, 2021
Harmonized language is critical for helping researchers to find data, collecting scientific data to facilitate comparison, and performing pooled and meta-analyses. Using standard terms to link data to knowledge systems facilitates knowledge-driven an...
Environmental Health National Institute of Environmental Health Sciences (U.S.) Language United States Knowledge Bases Artificial Intelligence
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Systematic review of Pharmacogenomics Knowledgebase evidence for pharmacogenomic links to the dopamine reward pathway for heroin dependence.

Pharmacogenomics Aug 23, 2021
Genetics play an important role in opioid use disorder (OUD); however, few specific gene variants have been identified. Therefore, there is a need to further understand the pharmacogenomics influences on the pharmacodynamics of opioids. The Pharmacog...
Biomarkers Animals Humans Heroin Dependence Reward Dopamine Neural Pathways Pharmacogenetics Knowledge Bases
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Compressing deep graph convolution network with multi-staged knowledge distillation.

PloS one Aug 13, 2021
Given a trained deep graph convolution network (GCN), how can we effectively compress it into a compact network without significant loss of accuracy? Compressing a trained deep GCN into a compact GCN is of great importance for implementing the model ...
Computer Graphics Neural Networks, Computer Knowledge Bases Datasets as Topic Humans
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Diffusion enables integration of heterogeneous data and user-driven learning in a desktop knowledge-base.

PLoS computational biology Aug 11, 2021
Integrating reference datasets (e.g. from high-throughput experiments) with unstructured and manually-assembled information (e.g. notes or comments from individual researchers) has the potential to tailor bioinformatic analyses to specific needs and ...
Database Management Systems Knowledge Bases Systems Integration Humans Learning User-Computer Interface Algorithms
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Excipient knowledgebase: Development of a comprehensive tool for understanding the disposition and interaction potential of common excipients.

CPT: pharmacometrics & systems pharmacology Aug 1, 2021
Although the use of excipients is widespread, a thorough understanding of the drug interaction potential of these compounds remains a frequent topic of current research. Not only can excipients alter the disposition of coformulated drugs, but it is l...
Glycerol Excipients Models, Biological ATP Binding Cassette Transporter, Subfamily B, Member 1 Knowledge Bases Cytochrome P-450 CYP3A Drug Interactions Humans Computer Simulation
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