AIMC Topic: Heroin Dependence

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Skin Microbiome alterations in heroin users revealed by full-length 16S rRNA sequencing.

BMC microbiology Jul 30, 2025
BACKGROUND: Identifying key characteristics of unknown suspects, such as age, height, and drug use, is essential for advancing forensic investigations.
Phylogeny Bacteria DNA, Bacterial Adult Male Humans Middle Aged Female Microbiota Young Adult Heroin RNA, Ribosomal, 16S Heroin Dependence Sequence Analysis, DNA Skin Microbiome Skin
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Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model.

Biological psychiatry Dec 25, 2024
BACKGROUND: Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior ...
Humans Machine Learning Adult Animals Heroin Male Rats Transcriptome Heroin Dependence Rats, Sprague-Dawley Prefrontal Cortex Drug-Seeking Behavior Disease Models, Animal
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Systematic review of Pharmacogenomics Knowledgebase evidence for pharmacogenomic links to the dopamine reward pathway for heroin dependence.

Pharmacogenomics Aug 23, 2021
Genetics play an important role in opioid use disorder (OUD); however, few specific gene variants have been identified. Therefore, there is a need to further understand the pharmacogenomics influences on the pharmacodynamics of opioids. The Pharmacog...
Pharmacogenetics Knowledge Bases Reward Humans Biomarkers Animals Dopamine Neural Pathways Heroin Dependence
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Machine learning: assessing neurovascular signals in the prefrontal cortex with non-invasive bimodal electro-optical neuroimaging in opiate addiction.

Scientific reports Dec 4, 2019
Chronic and recurrent opiate use injuries brain tissue and cause serious pathophysiological changes in hemodynamic and subsequent inflammatory responses. Prefrontal cortex (PFC) has been implicated in drug addiction. However, the mechanism underlying...
Male Middle Aged Prefrontal Cortex Functional Neuroimaging Pilot Projects Heroin Dependence Machine Learning Female Adult Humans
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Machine-learning identifies substance-specific behavioral markers for opiate and stimulant dependence.

Drug and alcohol dependence Feb 15, 2016
BACKGROUND: Recent animal and human studies reveal distinct cognitive and neurobiological differences between opiate and stimulant addictions; however, our understanding of the common and specific effects of these two classes of drugs remains limited...
Humans Antisocial Personality Disorder Personality Machine Learning Behavior, Addictive Female Young Adult Amphetamine-Related Disorders Heroin Dependence Risk Factors Adult Impulsive Behavior Male
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Exchanging expertise and constructing boundaries: The development of a transnational knowledge network around heroin-assisted treatment.

The International journal on drug policy Dec 17, 2015
Over the last 20 years, supervised injectable and inhalable heroin prescribing has been developed, tested and in some cases introduced as a second line treatment for limited groups of entrenched heroin users in a number of European countries and Cana...
Heroin Heroin Dependence Cooperative Behavior Behavior, Addictive Drug Users Evidence-Based Medicine Injections, Intravenous Humans International Cooperation Administration, Inhalation Analgesics, Opioid Qualitative Research Stakeholder Participation Public Opinion Knowledge Bases Treatment Outcome Interdisciplinary Communication
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A murdered teen, two million tweets and an experiment to fight gun violence.

Nature Sep 1, 2018
Researchers are using AI to decode the language of Chicago gangs. Next they’ll look for opportunities to intervene before online aggression turns deadly.
In the middle of the day on 11 April 2014, a hooded gunman ambushed Gakirah Barnes on the str...
Aggression Chicago Humans Artificial Intelligence Machine Learning Risk Female Firearms Reproducibility of Results Social Media Violence Young Adult Male Motivation Grief Anger Adolescent Drug Overdose Homicide Heroin Dependence Adolescent Behavior
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