AIMC Topic: Heroin Dependence

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Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model.

Biological psychiatry Dec 25, 2024
BACKGROUND: Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior ...
Male Transcriptome Prefrontal Cortex Adult Animals Heroin Heroin Dependence Drug-Seeking Behavior Rats, Sprague-Dawley Disease Models, Animal Rats Humans Machine Learning
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Systematic review of Pharmacogenomics Knowledgebase evidence for pharmacogenomic links to the dopamine reward pathway for heroin dependence.

Pharmacogenomics Aug 23, 2021
Genetics play an important role in opioid use disorder (OUD); however, few specific gene variants have been identified. Therefore, there is a need to further understand the pharmacogenomics influences on the pharmacodynamics of opioids. The Pharmacog...
Dopamine Neural Pathways Pharmacogenetics Heroin Dependence Knowledge Bases Biomarkers Animals Reward Humans
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Machine learning: assessing neurovascular signals in the prefrontal cortex with non-invasive bimodal electro-optical neuroimaging in opiate addiction.

Scientific reports Dec 4, 2019
Chronic and recurrent opiate use injuries brain tissue and cause serious pathophysiological changes in hemodynamic and subsequent inflammatory responses. Prefrontal cortex (PFC) has been implicated in drug addiction. However, the mechanism underlying...
Female Adult Male Humans Machine Learning Pilot Projects Heroin Dependence Prefrontal Cortex Functional Neuroimaging Middle Aged
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Machine-learning identifies substance-specific behavioral markers for opiate and stimulant dependence.

Drug and alcohol dependence Feb 15, 2016
BACKGROUND: Recent animal and human studies reveal distinct cognitive and neurobiological differences between opiate and stimulant addictions; however, our understanding of the common and specific effects of these two classes of drugs remains limited...
Amphetamine-Related Disorders Impulsive Behavior Behavior, Addictive Heroin Dependence Antisocial Personality Disorder Adult Male Humans Personality Machine Learning Risk Factors Female Young Adult
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Exchanging expertise and constructing boundaries: The development of a transnational knowledge network around heroin-assisted treatment.

The International journal on drug policy Dec 17, 2015
Over the last 20 years, supervised injectable and inhalable heroin prescribing has been developed, tested and in some cases introduced as a second line treatment for limited groups of entrenched heroin users in a number of European countries and Cana...
Cooperative Behavior Behavior, Addictive Drug Users Stakeholder Participation Interdisciplinary Communication Heroin Heroin Dependence Knowledge Bases Evidence-Based Medicine Public Opinion International Cooperation Administration, Inhalation Treatment Outcome Injections, Intravenous Analgesics, Opioid Humans Qualitative Research
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A murdered teen, two million tweets and an experiment to fight gun violence.

Nature Sep 1, 2018
Homicide Anger Male Adolescent Young Adult Social Media Motivation Firearms Adolescent Behavior Machine Learning Drug Overdose Violence Aggression Female Grief Risk Chicago Reproducibility of Results Humans Heroin Dependence Artificial Intelligence
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