AIMC Topic: Hydroxyurea

Clear Filters Showing 1 to 3 of 3 articles

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells.

Nature communications Aug 19, 2025
DNA replication stress is a hallmark of cancer that is exploited by chemotherapies. Current assays for replication stress have low throughput and poor resolution whilst being unable to map the movement of replication forks genome-wide. We present a n...
Humans Artificial Intelligence Melanoma Neoplasms Cell Line, Tumor Protein-Tyrosine Kinases Colonic Neoplasms Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins Poly (ADP-Ribose) Polymerase-1 Hydroxyurea Nanopores DNA Replication Nanopore Sequencing S Phase
View on PubMed DOI

Genetic dissection of complex traits using hierarchical biological knowledge.

PLoS computational biology Sep 17, 2021
Despite the growing constellation of genetic loci linked to common traits, these loci have yet to account for most heritable variation, and most act through poorly understood mechanisms. Recent machine learning (ML) systems have used hierarchical bio...
Neural Networks, Computer Machine Learning Phenotype Genome-Wide Association Study Polymorphism, Single Nucleotide Computational Biology Systems Biology Models, Genetic Metabolic Networks and Pathways Copper Mutation Glucose Glycine Knowledge Bases Saccharomyces cerevisiae Gene Ontology Hydroxyurea Chromosome Mapping Multifactorial Inheritance Benomyl Nucleotidyltransferases
View on PubMed DOI

Diagnosis and Management of Polycythemia Vera in a Ferret ().

Comparative medicine Dec 1, 2016
A 5-y-old female ferret (Mustela putorius furo) was evaluated for diarrhea, anorexia, and lethargy for 1 wk. Only mild dehydration was detected on physical examination. CBC analysis revealed marked erythrocytosis with an unremarkable plasma biochemis...
Female Animals Antineoplastic Agents Ultrasonography Diarrhea Radiography Erythropoietin Fatal Outcome Phlebotomy Ferrets Hydroxyurea Polycythemia Vera
View on PubMed
Popular Topics
Recent Journals