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Knowledge Bases

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How Employability Attributes Mediate the Link Between Knowledge Workers' Career Adaptation Concerns and Their Self-Perceived Employability.

Psychological reports
The study examines employability attributes as psychological mechanisms that explain the link between the career adaptation concerns and self-perceived employability of a sample of professionally qualified knowledge workers (N = 404). A cross-section...

An open access medical knowledge base for community driven diagnostic decision support system development.

BMC medical informatics and decision making
INTRODUCTION: While early diagnostic decision support systems were built around knowledge bases, more recent systems employ machine learning to consume large amounts of health data. We argue curated knowledge bases will remain an important component ...

The Interplay of Knowledge Representation with Various Fields of Artificial Intelligence in Medicine.

Yearbook of medical informatics
INTRODUCTION: Artificial intelligence (AI) is widespread in many areas, including medicine. However, it is unclear what exactly AI encompasses. This paper aims to provide an improved understanding of medical AI and its constituent fields, and their i...

PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison.

BMC bioinformatics
BACKGROUND: Pharmacogenomics (PGx) studies how genomic variations impact variations in drug response phenotypes. Knowledge in pharmacogenomics is typically composed of units that have the form of ternary relationships gene variant - drug - adverse ev...

Relation path feature embedding based convolutional neural network method for drug discovery.

BMC medical informatics and decision making
BACKGROUND: Drug development is an expensive and time-consuming process. Literature-based discovery has played a critical role in drug development and may be a supplementary method to help scientists speed up the discovery of drugs.

On building a diabetes centric knowledge base via mining the web.

BMC medical informatics and decision making
BACKGROUND: Diabetes has become one of the hot topics in life science researches. To support the analytical procedures, researchers and analysts expend a mass of labor cost to collect experimental data, which is also error-prone. To reduce the cost a...

An ontological framework for the formalization, organization and usage of TCM-Knowledge.

BMC medical informatics and decision making
BACKGROUND: The traditional Chinese Medicine Language System (TCMLS) is a large-scale terminology system, developed from 2002 on by the Institute of Information of Traditional Chinese Medicine (IITCM). Until now, more than 120,000 concepts, 300,000 t...

A knowledge-based system for brain tumor segmentation using only 3D FLAIR images.

Australasian physical & engineering sciences in medicine
This study aims to develop a semi-automatic system for brain tumor segmentation in 3D MR images. For a given image, noise was corrected using SUSAN algorithm first. A specific region of interest (ROI) that contains tumor was identified and then the i...

Stochastic frontier analysis as knowledge-based model to improve sparing of organs-at-risk for VMAT-treated prostate cancer.

Physics in medicine and biology
Stochastic frontier analysis (SFA) is used as a novel knowledge-based technique in order to develop a predictive model of dosimetric features from significant geometric parameters describing a patient morphology. 406 patients treated with VMAT for pr...

Machine learning applied to multi-sensor information to reduce false alarm rate in the ICU.

Journal of clinical monitoring and computing
Studies reveal that the false alarm rate (FAR) demonstrated by intensive care unit (ICU) vital signs monitors ranges from 0.72 to 0.99. We applied machine learning (ML) to ICU multi-sensor information to imitate a medical specialist in diagnosing pat...