AIMC Topic: Knowledge Bases
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Uncovering the structure of self-regulation through data-driven ontology discovery.
Nature communications
May 24, 2019
Psychological sciences have identified a wealth of cognitive processes and behavioral phenomena, yet struggle to produce cumulative knowledge. Progress is hamstrung by siloed scientific traditions and a focus on explanation over prediction, two issue...
MCRDR Knowledge-Based 3D Dialogue Simulation in Clinical Training and Assessment.
Journal of medical systems
May 23, 2019
Dialogue-based simulation is a real-world practice technique for medical and clinical education that provides students with an opportunity to train using hands-on experiences without putting actual patients being put at risk. In this paper, a 3D inte...
Knowledge-guided convolutional networks for chemical-disease relation extraction.
BMC bioinformatics
May 21, 2019
BACKGROUND: Automatic extraction of chemical-disease relations (CDR) from unstructured text is of essential importance for disease treatment and drug development. Meanwhile, biomedical experts have built many highly-structured knowledge bases (KBs), ...
Discrimination power of knowledge-based potential dictated by the dominant energies in native protein structures.
Amino acids
May 16, 2019
Extracting a well-designed energy function is important for protein structure evaluation. Knowledge-based potential functions are one type of the energy functions which can be obtained from known protein structures. The pairwise potential between ato...
Integrating Bonded and Nonbonded Potentials in the Knowledge-Based Scoring Function for Protein Structure Prediction.
Journal of chemical information and modeling
May 13, 2019
An accurate energy scoring function is crucial for protein structure prediction. Given the increasing number of experimentally determined structures, knowledge-based approaches have been widely used to develop scoring functions for protein structure ...
How Employability Attributes Mediate the Link Between Knowledge Workers' Career Adaptation Concerns and Their Self-Perceived Employability.
Psychological reports
May 6, 2019
The study examines employability attributes as psychological mechanisms that explain the link between the career adaptation concerns and self-perceived employability of a sample of professionally qualified knowledge workers (N = 404). A cross-section...
An open access medical knowledge base for community driven diagnostic decision support system development.
BMC medical informatics and decision making
Apr 27, 2019
INTRODUCTION: While early diagnostic decision support systems were built around knowledge bases, more recent systems employ machine learning to consume large amounts of health data. We argue curated knowledge bases will remain an important component ...
The Interplay of Knowledge Representation with Various Fields of Artificial Intelligence in Medicine.
Yearbook of medical informatics
Apr 25, 2019
INTRODUCTION: Artificial intelligence (AI) is widespread in many areas, including medicine. However, it is unclear what exactly AI encompasses. This paper aims to provide an improved understanding of medical AI and its constituent fields, and their i...
PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison.
BMC bioinformatics
Apr 18, 2019
BACKGROUND: Pharmacogenomics (PGx) studies how genomic variations impact variations in drug response phenotypes. Knowledge in pharmacogenomics is typically composed of units that have the form of ternary relationships gene variant - drug - adverse ev...
Relation path feature embedding based convolutional neural network method for drug discovery.
BMC medical informatics and decision making
Apr 9, 2019
BACKGROUND: Drug development is an expensive and time-consuming process. Literature-based discovery has played a critical role in drug development and may be a supplementary method to help scientists speed up the discovery of drugs.
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