AIMC Topic: Knowledge Bases
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A concept ideation framework for medical device design.
Journal of biomedical informatics
May 6, 2015
Medical device design is a challenging process, often requiring collaboration between medical and engineering domain experts. This collaboration can be best institutionalized through systematic knowledge transfer between the two domains coupled with ...
Point-of-Care Knowledge-Based Resource Needs of Clinicians: A Survey from a Large Academic Medical Center.
Applied clinical informatics
May 6, 2015
OBJECTIVE: To better understand the literature searching preferences of clinical providers we conducted an institution-wide survey assessing the most preferred knowledge searching techniques.
The SwissLipids knowledgebase for lipid biology.
Bioinformatics (Oxford, England)
May 5, 2015
MOTIVATION: Lipids are a large and diverse group of biological molecules with roles in membrane formation, energy storage and signaling. Cellular lipidomes may contain tens of thousands of structures, a staggering degree of complexity whose significa...
The potential of AOP networks for reproductive and developmental toxicity assay development.
Reproductive toxicology (Elmsford, N.Y.)
Apr 15, 2015
Historically, the prediction of reproductive and developmental toxicity has largely relied on the use of animals. The adverse outcome pathway (AOP) framework forms a basis for the development of new non-animal test methods. It also provides biologica...
Gene Expression Regulation, Developmental
Humans
Computer Simulation
Pregnancy
Female
Reproduction
Embryonic Development
Toxicity Tests
Animals
Signal Transduction
Animal Testing Alternatives
Risk Assessment
Systems Integration
Gene Regulatory Networks
Fetal Development
Models, Biological
Knowledge Bases
DyKOSMap: A framework for mapping adaptation between biomedical knowledge organization systems.
Journal of biomedical informatics
Apr 15, 2015
BACKGROUND: Knowledge Organization Systems (KOS) and their associated mappings play a central role in several decision support systems. However, by virtue of knowledge evolution, KOS entities are modified over time, impacting mappings and potentially...
Non-redundant association rules between diseases and medications: an automated method for knowledge base construction.
BMC medical informatics and decision making
Apr 15, 2015
BACKGROUND: The widespread use of electronic health records (EHRs) has generated massive clinical data storage. Association rules mining is a feasible technique to convert this large amount of data into usable knowledge for clinical decision making, ...
Incorporating linguistic knowledge for learning distributed word representations.
PloS one
Apr 13, 2015
Combined with neural language models, distributed word representations achieve significant advantages in computational linguistics and text mining. Most existing models estimate distributed word vectors from large-scale data in an unsupervised fashio...
A knowledge-based algorithm for automatic detection of cephalometric landmarks on CBCT images.
International journal of computer assisted radiology and surgery
Apr 7, 2015
PURPOSE: Cone-beam computed tomography (CBCT) is now an established component for 3D evaluation and treatment planning of patients with severe malocclusion and craniofacial deformities. Precision landmark plotting on 3D images for cephalometric analy...
The Quebec rural emergency department project: a cross-sectional study of a potential two-pronged strategy in the knowledge transfer process.
PloS one
Apr 7, 2015
INTRODUCTION: Health services research generates useful knowledge. Promotion of implementation of this knowledge in medical practice is essential. Prior to initiation of a major study on rural emergency departments (EDs), we deployed two knowledge tr...
Using the Knowledge Base of Health Services Research to Redefine Health Care Systems.
Journal of general internal medicine
Apr 4, 2015
This Perspective discusses 12 key facts derived from 50 years of health services research and argues that this knowledge base can stimulate innovative thinking about how to make health care systems safer, more efficient, more cost effective, and more...
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