AIMC Topic: Knowledge Bases
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Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction.
Bioinformatics (Oxford, England)
May 1, 2017
MOTIVATION: Loops are often vital for protein function, however, their irregular structures make them difficult to model accurately. Current loop modelling algorithms can mostly be divided into two categories: knowledge-based, where databases of frag...
The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations.
Journal of the American Medical Informatics Association : JAMIA
May 1, 2017
OBJECTIVE: This paper describes the Precision Medicine Knowledge Base (PMKB; https://pmkb.weill.cornell.edu ), an interactive online application for collaborative editing, maintenance, and sharing of structured clinical-grade cancer mutation interpre...
Planning bioinformatics workflows using an expert system.
Bioinformatics (Oxford, England)
Apr 15, 2017
MOTIVATION: Bioinformatic analyses are becoming formidably more complex due to the increasing number of steps required to process the data, as well as the proliferation of methods that can be used in each step. To alleviate this difficulty, pipelines...
FARNA: knowledgebase of inferred functions of non-coding RNA transcripts.
Nucleic acids research
Mar 17, 2017
Non-coding RNA (ncRNA) genes play a major role in control of heterogeneous cellular behavior. Yet, their functions are largely uncharacterized. Current available databases lack in-depth information of ncRNA functions across spectrum of various cells/...
CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer.
Nature genetics
Jan 31, 2017
CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types. CIViC is committed to open-s...
Using an Ontology-Based Approach to Handle Author Affiliations in a Large Biomedical Citation Database.
Studies in health technology and informatics
Jan 1, 2017
To handle differences in affiliation names submitted with biomedical journal articles, we build an affiliation knowledge base named Authority File for Affiliations (AFA) based on ontology principles. There are currently 113,700 affiliation concepts w...
Bringing Knowledge to Users in One Click: Infobuttons in the Problem List of an EHR.
Studies in health technology and informatics
Jan 1, 2017
The infobuttons allows the solving of information needs. In our study, the use of Infobuttons is described, analyzing the number of queries to UpToDate® from the problem list of an Electronic Health Record. There were 26419 requests in 8 months. The ...
CD-KES: An Ontology Based Knowledge Education System for Patients with Chronic Diseases and Its Constructing Approach.
Studies in health technology and informatics
Jan 1, 2017
Patients' participation plays a crucial role in the management of chronic diseases. Educating patients about their diseases allows patients to self-regulate their daily health conditions more reasonably and effectively. This study focuses on an infor...
Development of a Service-Oriented Sharable Clinical Decision Support System Based on Ontology for Chronic Disease.
Studies in health technology and informatics
Jan 1, 2017
Clinical decision support systems (CDSSs) have been proved as an efficient way to improve health care quality. However, the inflexibility in integrating multiple clinical practice guidelines (multi-CPGs), the mass input workload of patient data, and ...
Adverse Drug Event Monitoring with Clinical and Laboratory Data Using Arden Syntax.
Studies in health technology and informatics
Jan 1, 2017
In times of steadily increasing numbers of administered drugs, the detection of adverse drug events (ADEs) is an important aspect of improving patient safety. At present only about 1-13% of detected ADEs are reported. Raising the number of reported A...
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