Hepatocellular carcinoma (HCC) is an aggressive cancer with limited biomarkers for predicting immunotherapy response. Recent advancements in large language models (LLMs) like GPT-4, GPT-4o, and Gemini offer the potential for enhancing clinical decisi...
Therapeutic innovation & regulatory science
May 13, 2025
BACKGROUND: As described in ICH E3 Q&A R1 (International Council for Harmonisation. E3: Structure and content of clinical study reports-questions and answers (R1). 6 July 2012. Available from: https://database.ich.org/sites/default/files/E3_Q%26As_R1...
BACKGROUND: Despite significant advances in AI-driven medical diagnostics, the integration of large language models (LLMs) into psychiatric practice presents unique challenges. While LLMs demonstrate high accuracy in controlled settings, their perfor...
This study explores the use of open-source large language models (LLMs) to automate generation of German discharge summaries from structured clinical data. The structured data used to produce AI-generated summaries were manually extracted from electr...
BACKGROUND: Systematic reviews (SRs) are essential to formulate evidence-based guidelines but require time-consuming and costly literature screening. Large Language Models (LLMs) can be a powerful tool to expedite SRs.
Proceedings of the National Academy of Sciences of the United States of America
May 9, 2025
What mechanisms underlie linguistic generalization in large language models (LLMs)? This question has attracted considerable attention, with most studies analyzing the extent to which the language skills of LLMs resemble rules. As of yet, it is not k...
INTRODUCTION: Patients increasingly use large language models for health-related information, but their reliability and usefulness remain controversial. Continuous assessment is essential to evaluate their role in patient education. This study evalua...
BACKGROUND: Mental health is emerging as an increasingly prevalent public issue globally. There is an urgent need in mental health for efficient detection methods, effective treatments, affordable privacy-focused health care solutions, and increased ...
IMPORTANCE: Large language models (LLMs) have not yet been compared with traditional diagnostic decision support systems (DDSSs) on unpublished clinical cases.
BACKGROUND: Large language models (LLMs) are transforming how data is used, including within the health care sector. However, frameworks including the Unified Theory of Acceptance and Use of Technology highlight the importance of understanding the fa...
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