Studies in health technology and informatics
Apr 8, 2025
Chronic lymphocytic leukemia (CLL) exhibits a heterogeneous clinical course. Prognostic markers that impact patient outcomes have been identified, including MYC gene abnormalities. This study investigates machine learning (ML) models for predicting s...
Studies in health technology and informatics
Aug 22, 2024
Heterogeneity in chronic malignancies raises an increasing interest for the integration and study of predictive models. This study presents a machine learning model approach to predict outcomes and improve their trustworthiness in multi-factorial dis...
American journal of clinical pathology
Mar 3, 2022
OBJECTIVES: We desired an automated approach to expedite ordering additional antibody panels in our clinical flow cytometry lab. This addition could improve turnaround times, decrease time spent revisiting cases, and improve consistency.
Archives of pathology & laboratory medicine
Jan 2, 2022
CONTEXT.—: Large cell transformation (LCT) of indolent B-cell lymphomas, such as follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), signals a worse prognosis, at which point aggressive chemotherapy is initiated. Although LCT is relative...
Journal of the American Medical Informatics Association : JAMIA
Jul 1, 2020
OBJECTIVE: Unsupervised machine learning approaches hold promise for large-scale clinical data. However, the heterogeneity of clinical data raises new methodological challenges in feature selection, choosing a distance metric that captures biological...
Combinatorial chemistry & high throughput screening
Jan 1, 2020
AIM AND OBJECTIVE: Leukemia is the second common blood cancer after lymphoma, and its incidence rate has an increasing trend in recent years. Leukemia can be classified into four types: acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML)...
PURPOSE: Time to event is an important aspect of clinical decision making. This is particularly true when diseases have highly heterogeneous presentations and prognoses, as in chronic lymphocytic lymphoma (CLL). Although machine learning methods can ...
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