Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Jun 1, 2018
The survival of patients undergoing hematopoietic cell transplantation (HCT) from unrelated donors for acute leukemia exhibits considerable variation, even after stringent genetic matching. To improve the donor selection process, we attempted to crea...
This paper presents a novel method for salient object detection in nature image by simulating microsaccades in fixational eye movements. Due to a nucleated cell usually stained that is salient obviously, the proposed method is suitable to segment nuc...
Assay and drug development technologies
Jan 1, 2018
There is a large amount of information in brightfield images that was previously inaccessible by using traditional microscopy techniques. This information can now be exploited by using machine-learning approaches for both image segmentation and the c...
Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to de...
The identification of a subset of genes having the ability to capture the necessary information to distinguish classes of patients is crucial in bioinformatics applications. Ensemble and bagging methods have been shown to work effectively in the proc...
This research proposes an intelligent decision support system for acute lymphoblastic leukaemia diagnosis from microscopic blood images. A novel clustering algorithm with stimulating discriminant measures (SDM) of both within- and between-cluster sca...
International journal of data mining and bioinformatics
Jan 1, 2015
High-dimensional data and a large number of redundancy features in bioinformatics research have created an urgent need for feature selection. In this paper, a novel random forests-based feature selection method is proposed that adopts the idea of str...
We present a new genetic filter to identify a predictive gene subset for cancer-type classification on gene expression profiles. This approach pursues to not only maximize correlation between selected genes and cancer types but also minimize inter-co...
Studies in health technology and informatics
Jan 1, 2015
The goal of our study is to establish methodological guidelines for the formulation of definitions in biomedical ontologies thatare not so common in the field of Library & Information Science.