BACKGROUND: Signaling proteins such as protein kinases adopt a diverse array of conformations to respond to regulatory signals in signaling pathways. Perhaps the most fundamental conformational change of a kinase is the transition between active and ...
Plasmonic sensors have been used for a wide range of biological and chemical sensing applications. Emerging nanofabrication techniques have enabled these sensors to be cost-effectively mass manufactured onto various types of substrates. To accompany ...
International journal of molecular sciences
Feb 1, 2017
Reverse vaccinology (RV) is a bioinformatics approach that can predict antigens with protective potential from the protein coding genomes of bacterial pathogens for subunit vaccine design. RV has become firmly established following the development of...
AJR. American journal of roentgenology
Jan 31, 2017
OBJECTIVE: The purpose of this study is to evaluate the performance of a natural language processing (NLP) system in classifying a database of free-text knee MRI reports at two separate academic radiology practices.
Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial...
Computational intelligence and neuroscience
Jan 30, 2017
Class imbalance ubiquitously exists in real life, which has attracted much interest from various domains. Direct learning from imbalanced dataset may pose unsatisfying results overfocusing on the accuracy of identification and deriving a suboptimal m...
Neural networks : the official journal of the International Neural Network Society
Jan 28, 2017
Although Hebbian learning has long been a key component in understanding neural plasticity, it has not yet been successful in modeling modulatory feedback connections, which make up a significant portion of connections in the brain. We develop a new ...
We present an integrated methodology for detecting, segmenting and classifying breast masses from mammograms with minimal user intervention. This is a long standing problem due to low signal-to-noise ratio in the visualisation of breast masses, combi...
BACKGROUND: When left untreated, age-related macular degeneration (AMD) is the leading cause of vision loss in people over fifty in the US. Currently it is estimated that about eight million US individuals have the intermediate stage of AMD that is o...
In genome-wide association studies (GWAS), the acquired sequential data may exhibit imbalance structure: abundant control vs. limited case samples. Such sample imbalance issue is particularly serious when investigating rare diseases or common disease...
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