Studies in health technology and informatics
Jan 14, 2022
Population Health Management typically relies on subjective decisions to segment and stratify populations. This study combines unsupervised clustering for segmentation and supervised classification, personalised to clusters, for stratification. An in...
Hydrophobic interactions drive numerous biological and synthetic processes. The materials used in these processes often possess chemically heterogeneous surfaces that are characterized by diverse chemical groups positioned in close proximity at the n...
MOTIVATION: As one of the most important post-translational modifications (PTMs), protein lysine crotonylation (Kcr) has attracted wide attention, which involves in important physiological activities, such as cell differentiation and metabolism. Howe...
Journal of the American Medical Informatics Association : JAMIA
Jan 12, 2022
There has been increased excitement around the use of machine learning (ML) and artificial intelligence (AI) in dermatology for the diagnosis of skin cancers and assessment of other dermatologic conditions. As these technologies continue to expand, i...
Proceedings of the National Academy of Sciences of the United States of America
Jan 4, 2022
RAS is a signaling protein associated with the cell membrane that is mutated in up to 30% of human cancers. RAS signaling has been proposed to be regulated by dynamic heterogeneity of the cell membrane. Investigating such a mechanism requires near-at...
OBJECTIVES: The objectives of this study were to test in real time a Trauma Triage, Treatment, and Training Decision Support (4TDS) machine learning (ML) model of shock detection in a prospective silent trial, and to evaluate specificity, sensitivity...
MOTIVATION: Applications in synthetic and systems biology can benefit from measuring whole-cell response to biochemical perturbations. Execution of experiments to cover all possible combinations of perturbations is infeasible. In this paper, we prese...
Archives of pathology & laboratory medicine
Jan 2, 2022
CONTEXT.—: Large cell transformation (LCT) of indolent B-cell lymphomas, such as follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), signals a worse prognosis, at which point aggressive chemotherapy is initiated. Although LCT is relative...
Critical reviews in biomedical engineering
Jan 1, 2022
Cancer has been the deadliest of diseases since decades constituting a large number of deaths annually. Lung cancer remains one of the most significant public health issues, accounting for a substantial proportion of cancer-related deaths globally. D...
IEEE computer graphics and applications
Jan 1, 2022
Understanding the interpretation of machine learning (ML) models has been of paramount importance when making decisions with societal impacts, such as transport control, financial activities, and medical diagnosis. While local explanation techniques ...
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