AIMC Topic: Proto-Oncogene Proteins p21(ras)
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Comparison of Intratumoral and Peritumoral Deep Learning, Radiomics, and Fusion Models for Predicting KRAS Gene Mutations in Rectal Cancer Based on Endorectal Ultrasound Imaging.
Annals of surgical oncology
Dec 17, 2024
MAIN OBJECTIVES: We aimed at comparing intratumoral and peritumoral deep learning, radiomics, and fusion models in predicting KRAS mutations in rectal cancer using endorectal ultrasound imaging.
Conformations of KRAS4B Affected by Its Partner Binding and G12C Mutation: Insights from GaMD Trajectory-Image Transformation-Based Deep Learning.
Journal of chemical information and modeling
Aug 28, 2024
Binding of partners and mutations highly affects the conformational dynamics of KRAS4B, which is of significance for deeply understanding its function. Gaussian accelerated molecular dynamics (GaMD) simulations followed by deep learning (DL) and prin...
CHNet: A multi-task global-local Collaborative Hybrid Network for KRAS mutation status prediction in colorectal cancer.
Artificial intelligence in medicine
Jul 5, 2024
Accurate prediction of Kirsten rat sarcoma (KRAS) mutation status is crucial for personalized treatment of advanced colorectal cancer patients. However, despite the excellent performance of deep learning models in certain aspects, they often overlook...
Molecular Mechanism of Phosphorylation-Mediated Impacts on the Conformation Dynamics of GTP-Bound KRAS Probed by GaMD Trajectory-Based Deep Learning.
Molecules (Basel, Switzerland)
May 15, 2024
The phosphorylation of different sites produces a significant effect on the conformational dynamics of KRAS. Gaussian accelerated molecular dynamics (GaMD) simulations were combined with deep learning (DL) to explore the molecular mechanism of the ph...
Deep neural network for the prediction of KRAS, NRAS, and BRAF genotypes in left-sided colorectal cancer based on histopathologic images.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
May 12, 2024
BACKGROUND: The KRAS, NRAS, and BRAF genotypes are critical for selecting targeted therapies for patients with metastatic colorectal cancer (mCRC). Here, we aimed to develop a deep learning model that utilizes pathologic whole-slide images (WSIs) to ...
Accuracy of machine learning in preoperative identification of genetic mutation status in lung cancer: A systematic review and meta-analysis.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
May 10, 2024
BACKGROUND AND PURPOSE: We performed this systematic review and meta-analysis to investigate the performance of ML in detecting genetic mutation status in NSCLC patients.
Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model.
Microbiology spectrum
Apr 4, 2024
Gut microbiota has demonstrated an increasingly important role in the onset and development of colorectal cancer (CRC). Nonetheless, the association between gut microbiota and KRAS mutation in CRC remains enigmatic. We conducted 16S rRNA sequencing o...
Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: A retrospective multi-centric study.
Cell reports. Medicine
Mar 22, 2023
Deep learning (DL) can predict microsatellite instability (MSI) from routine histopathology slides of colorectal cancer (CRC). However, it is unclear whether DL can also predict other biomarkers with high performance and whether DL predictions genera...
A Deep Learning Model Based on MRI and Clinical Factors Facilitates Noninvasive Evaluation of KRAS Mutation in Rectal Cancer.
Journal of magnetic resonance imaging : JMRI
May 19, 2022
BACKGROUND: Recent studies showed the potential of MRI-based deep learning (DL) for assessing treatment response in rectal cancer, but the role of MRI-based DL in evaluating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation remains unclear...
Editorial for "A Deep Learning Model Based on MRI and Clinical Factors Facilitates Noninvasive Prediction of KRAS Mutation in Rectal Cancer".
Journal of magnetic resonance imaging : JMRI
May 16, 2022
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