AIMC Topic: Mesalamine
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Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery.
Journal of controlled release : official journal of the Controlled Release Society
Aug 12, 2024
Colonic drug delivery offers numerous pharmaceutical opportunities, including direct access to local therapeutic targets and drug bioavailability benefits arising from the colonic epithelium's reduced abundance of cytochrome P450 enzymes and particul...
Combining explainable machine learning, demographic and multi-omic data to inform precision medicine strategies for inflammatory bowel disease.
PloS one
Feb 23, 2022
Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, affect several million individuals worldwide. These diseases are heterogeneous at the clinical, immunological and genetic levels and result from complex host and en...
Colitis, Ulcerative
Anti-Inflammatory Agents, Non-Steroidal
Signal Transduction
Pyrazoles
Phenylurea Compounds
Drug Evaluation, Preclinical
Crohn Disease
Transcriptome
Middle Aged
Genomics
Adolescent
Adult
Male
Young Adult
Naphthalenes
Mesalamine
Precision Medicine
Tumor Necrosis Factor-alpha
Aged
Prednisolone
Female
Humans
Machine Learning
A machine learning approach identifies 5-ASA and ulcerative colitis as being linked with higher COVID-19 mortality in patients with IBD.
Scientific reports
Aug 13, 2021
Inflammatory bowel diseases (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammation within the gastrointestinal tract. IBD patient conditions and treatments, such as with immunosuppressants, may result in a higher risk...
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