AIMC Topic: Metabolic Networks and Pathways

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Metabolomics profile and machine learning prediction of treatment responses in immune thrombocytopenia: A prospective cohort study.

British journal of haematology Mar 4, 2024
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by antibody-mediated platelet destruction and impaired platelet production. The mechanisms underlying ITP and biomarkers predicting the response of drug treatments are elusive. We p...
Treatment Outcome Metabolomics Male Middle Aged Bone Marrow Purpura, Thrombocytopenic, Idiopathic Metabolome Metabolic Networks and Pathways Biomarkers Female Aged Adult Machine Learning Prospective Studies Humans
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Multi-label classification with XGBoost for metabolic pathway prediction.

BMC bioinformatics Feb 1, 2024
BACKGROUND: Metabolic pathway prediction is one possible approach to address the problem in system biology of reconstructing an organism's metabolic network from its genome sequence. Recently there have been developments in machine learning-based pat...
Metabolic Networks and Pathways Biology Machine Learning Genome
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Integrative deep learning framework predicts lipidomics-based investigation of preservatives on meat nutritional biomarkers and metabolic pathways.

Critical reviews in food science and nutrition Dec 21, 2023
Preservatives are added as antimicrobial agents to extend the shelf life of meat. Adding preservatives to meat products can affect their flavor and nutrition. This review clarifies the effects of preservatives on metabolic pathways and network molecu...
Nutritive Value Lipidomics Meat Meat Products Triglycerides Deep Learning Proteomics Food Preservatives Metabolic Networks and Pathways Biomarkers Animals Humans Neural Networks, Computer
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Deep learning for metabolic pathway design.

Metabolic engineering Sep 19, 2023
The establishment of a bio-based circular economy is imperative in tackling the climate crisis and advancing sustainable development. In this realm, the creation of microbial cell factories is central to generating a variety of chemicals and material...
Deep Learning Metabolic Networks and Pathways Metabolic Engineering
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DeepRT: Predicting compounds presence in pathway modules and classifying into module classes using deep neural networks based on molecular properties.

Journal of bioinformatics and computational biology Aug 24, 2023
Metabolic pathways play a crucial role in understanding the biochemistry of organisms. In metabolic pathways, modules refer to clusters of interconnected reactions or sub-networks representing specific functional units or biological processes within ...
Neural Networks, Computer Deep Learning Metabolic Networks and Pathways
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Modeling of astaxanthin biosynthesis via machine learning, mathematical and metabolic network modeling.

Critical reviews in biotechnology Aug 16, 2023
Natural astaxanthin is synthesized by diverse organisms including: bacteria, fungi, microalgae, and plants involving complex cellular processes, which depend on numerous interrelated parameters. Nonetheless, existing knowledge regarding astaxanthin b...
Machine Learning Xanthophylls Models, Biological Bacteria Microalgae Metabolic Networks and Pathways
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Message Passing Neural Networks Improve Prediction of Metabolite Authenticity.

Journal of chemical information and modeling Mar 16, 2023
Cytochrome P450 enzymes aid in the elimination of a preponderance of small molecule drugs, but can generate reactive metabolites that may adversely react with protein and DNA and prompt drug candidate attrition or market withdrawal. Previously develo...
Molecular Structure Terbinafine Neural Networks, Computer Metabolic Networks and Pathways Humans
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Exploring the expressiveness of abstract metabolic networks.

PloS one Feb 9, 2023
Metabolism is characterised by chemical reactions linked to each other, creating a complex network structure. The whole metabolic network is divided into pathways of chemical reactions, such that every pathway is a metabolic function. A simplified re...
Models, Biological Machine Learning Metabolic Networks and Pathways
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Metabolic engineering for sustainability and health.

Trends in biotechnology Jan 10, 2023
Bio-based production of chemicals and materials has attracted much attention due to the urgent need to establish sustainability and enhance human health. Metabolic engineering (ME) allows purposeful modification of cellular metabolic, regulatory, and...
Artificial Intelligence Systems Biology Humans Metabolic Engineering Metabolic Networks and Pathways Synthetic Biology
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A novel hybrid framework for metabolic pathways prediction based on the graph attention network.

BMC bioinformatics Sep 28, 2022
BACKGROUND: Making clear what kinds of metabolic pathways a drug compound involves in can help researchers understand how the drug is absorbed, distributed, metabolized, and excreted. The characteristics of a compound such as structure, composition a...
Metabolic Networks and Pathways Drug Discovery Machine Learning Pharmaceutical Preparations Deep Learning
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