Ischemic stroke (IS) is a highly complex and heterogeneous disease involving multiple pathophysiological events. A better understanding of the pathophysiology of IS will enhance preventive, diagnostic and therapeutic strategies. Despite significant a...
The intersection of modern artificial intelligence (AI) and mass spectrometry (MS) is set to transform the MS-based "omics" research fields, particularly proteomics, metabolomics, lipidomics, and glycomics, enabling advancements across a wide range o...
Enhancing the understanding of attention-deficit/hyperactivity disorder (ADHD) by linking biological processes with behavioral manifestations is a primary objective of the Research Domain Criteria (RDoC) framework, which aims to transcend traditional...
Computer methods and programs in biomedicine
Aug 1, 2025
BACKGROUND AND OBJECTIVE: In recent years, the association between metabolites and complex human diseases has increasingly been recognized as a major research focus. Traditional wet-lab experiments are considered time-consuming and labor-intensive, w...
The increasing global demand for herbs and spices in food and nutraceutical industries highlights their key functional benefits, including antioxidant and anti-inflammatory properties. Ensuring authenticity and traceability is essential to counteract...
MS/MS-based untargeted metabolomics generates complex data, but pathway enrichment analysis is constrained by the low annotation rates of metabolic features. Here, we propose MS2MP, a novel deep learning-based framework for KEGG pathway prediction di...
Clinica chimica acta; international journal of clinical chemistry
Jul 15, 2025
Primary Central Nervous System Lymphoma (PCNSL) is a rare and aggressive type of hematological malignancy that can pose diagnostic challenges. Early detection is critical for effective treatment and better patient outcomes. The goal of this study was...
Journal of pharmaceutical and biomedical analysis
Jul 15, 2025
Arsenic (As)-induced hypertension is a significant public health concern, highlighting the need for early risk prediction. This study aimed to develop a predictive model for occupational As exposure and hypertension using metabolomics and machine lea...
Identification of compounds with minimal ambiguity remains a central challenge in mass spectrometry-based metabolomics. Conventional compound identification relies on comparing analytical signatures (e.g., mass-to-charge ratio, collision cross sectio...
Cow's milk protein allergy (CMA) is one of the most common food allergies in children worldwide. However, it is still not well understood why certain children outgrow their CMA and others do not. While there is increasing evidence for a link of CMA w...
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