AIMC Topic: Methyltransferases

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In Silico Prediction of O⁶-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods.

Molecules (Basel, Switzerland) Nov 6, 2018
O⁶-methylguanine-DNA methyltransferase (MGMT), a unique DNA repair enzyme, can confer resistance to DNA anticancer alkylating agents that modify the O⁶-position of guanine. Thus, inhibition of MGMT activity in tumors has a great interest for cancer r...
Antineoplastic Agents, Alkylating Humans Apoptosis Linear Models Methyltransferases Algorithms Quantitative Structure-Activity Relationship Machine Learning Animals
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Photoelectrochemical biosensor for HEN1 RNA methyltransferase detection using peroxidase mimics PtCu NFs and poly(U) polymerase-mediated RNA extension.

Biosensors & bioelectronics Dec 21, 2017
2'-O-methyl group on the 3' terminal nucleotide in plant microRNAs, as one kind of RNA methylations, is caused by HEN1 RNA methyltransferase (HENMT1), which is thought to be crucial for ribosome biogenesis and function. Herein, a simple and label-fre...
Nitriles Humans Peroxidase Copper S-Adenosylmethionine Nanocomposites Platinum Graphite Biosensing Techniques Methyltransferases Quantum Dots
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CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Journal of chemical information and modeling Jul 14, 2025
A critical assessment of computational hit-finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target. Twenty-three participating teams comprised of co...
Ligands SARS-CoV-2 Molecular Docking Simulation COVID-19 Drug Treatment Drug Discovery Protein Binding Binding Sites RNA, Viral Machine Learning Antiviral Agents RNA Helicases Methyltransferases COVID-19 Humans Viral Nonstructural Proteins
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Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning.

Nucleic acids research Sep 20, 2021
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotic mRNAs and influences many aspects of RNA processing. miCLIP (m6A individual-nucleotide resolution UV crosslinking and immunoprecipitation) is an antibody-based appr...
HEK293 Cells Methyltransferases RNA, Messenger Mouse Embryonic Stem Cells RNA Processing, Post-Transcriptional Nucleotide Motifs Adenosine Sensitivity and Specificity Animals RNA-Seq Mice Humans Machine Learning
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[Alpinetin promotes the binding of PPAR and methyltransferase].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Dec 1, 2017
Objective To screen the nucleus located-methyltransferase in murine macrophages (RAW246.7 cells) after peroxisome proliferator-activated receptors (PPAR) is activated by alpinetin so as to prove the epigenetic modification effect of alpinetin. Method...
Peroxisome Proliferator-Activated Receptors Computational Biology Animals Cells, Cultured Flavanones Mice Cell Nucleus Methyltransferases Anilides
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