AIMC Topic: Mice
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Structural characterization and osteogenic bioactivity of a sulfated polysaccharide from pacific abalone (Haliotis discus hannai Ino).
Carbohydrate polymers
Nov 6, 2017
Bone morphogenic protein-2 (BMP-2) is known to promote osteogenesis. To find novel adjuvants to enhance the activity of BMP-2, the present study investigated the structure BMP-2-induced osteogenic activity of a water-soluble polysaccharide from the g...
ToBio: Global Pathway Similarity Search Based on Topological and Biological Features.
IEEE/ACM transactions on computational biology and bioinformatics
Nov 3, 2017
Pathway similarity search plays a vital role in the post-genomics era. Unfortunately, pathway similarity search involves the graph isomorphism problem which is NP-complete. Therefore, efficient search algorithms are desirable. In this work, we propos...
Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway.
Food research international (Ottawa, Ont.)
Oct 27, 2017
This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. ...
A Support Vector Machine based method to distinguish long non-coding RNAs from protein coding transcripts.
BMC genomics
Oct 18, 2017
BACKGROUND: In recent years, a rapidly increasing number of RNA transcripts has been generated by thousands of sequencing projects around the world, creating enormous volumes of transcript data to be analyzed. An important problem to be addressed whe...
A Machine Learning Assisted, Label-free, Non-invasive Approach for Somatic Reprogramming in Induced Pluripotent Stem Cell Colony Formation Detection and Prediction.
Scientific reports
Oct 18, 2017
During cellular reprogramming, the mesenchymal-to-epithelial transition is accompanied by changes in morphology, which occur prior to iPSC colony formation. The current approach for detecting morphological changes associated with reprogramming purely...
Sparse Supervised Classification Methods Predict and Characterize Nanomaterial Exposures: Independent Markers of MWCNT Exposures.
Toxicologic pathology
Sep 22, 2017
Recent experimental evidence indicates significant pulmonary toxicity of multiwalled carbon nanotubes (MWCNTs), such as inflammation, interstitial fibrosis, granuloma formation, and carcinogenicity. Although numerous studies explored the adverse pote...
Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis.
Journal of environmental sciences (China)
Sep 8, 2017
Environmental exposure and health risk upon engineered nanomaterials are increasingly concerned. The family of mesoporous carbon nanomaterials (MCNs) is a rising star in nanotechnology for multidisciplinary research with versatile applications in ele...
Nano-topography Enhances Communication in Neural Cells Networks.
Scientific reports
Aug 29, 2017
Neural cells are the smallest building blocks of the central and peripheral nervous systems. Information in neural networks and cell-substrate interactions have been heretofore studied separately. Understanding whether surface nano-topography can dir...
A Machine Learning Approach to Automated Gait Analysis for the Noldus Catwalk System.
IEEE transactions on bio-medical engineering
Aug 24, 2017
OBJECTIVE: Gait analysis of animal disease models can provide valuable insights into in vivo compound effects and thus help in preclinical drug development. The purpose of this paper is to establish a computational gait analysis approach for the Nold...
Phase contrast cell detection using multilevel classification.
International journal for numerical methods in biomedical engineering
Aug 23, 2017
In this paper, we propose a fully automated learning-based approach for detecting cells in time-lapse phase contrast images. The proposed system combines 2 machine learning approaches to achieve bottom-up image segmentation. We apply pixel-wise class...
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