AIMC Topic: Microfluidic Analytical Techniques
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Point-of-Care Testing: The Convergence of Innovation and Accessibility in Diagnostics.
Analytical chemistry
May 13, 2025
Over the years, the evolution of point-of-care testing (POCT) has been driven by technological advancements in materials, design, and artificial intelligence, as well as breakthrough developments in wearable technologies. These innovations are shifti...
Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease.
Proceedings of the National Academy of Sciences of the United States of America
Mar 30, 2021
Understanding the mechanics of blood flow is necessary for developing insights into mechanisms of physiology and vascular diseases in microcirculation. Given the limitations of technologies available for assessing in vivo flow fields, in vitro method...
Red blood cell classification in lensless single random phase encoding using convolutional neural networks.
Optics express
Oct 26, 2020
Rapid cell identification is achieved in a compact and field-portable system employing single random phase encoding to record opto-biological signatures of living biological cells of interest. The lensless, 3D-printed system uses a diffuser to encode...
A new method using machine learning for automated image analysis applied to chip-based digital assays.
The Analyst
May 13, 2019
Chip-based digital assays such as the digital polymerase chain reaction (digital PCR), digital loop-mediated amplification (digital LAMP), digital enzyme-linked immunosorbent assay (digital ELISA) and digital proximity ligation assay (digital PLA) ne...
Modular soft robotic microdevices for dexterous biomanipulation.
Lab on a chip
Feb 26, 2019
We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices. Our strategy combines several advanced techniques including programmable colloidal self-assembly, light-harvesting with plasmonic nanotra...
Engineering reaction-diffusion networks with properties of neural tissue.
Lab on a chip
Feb 27, 2018
We present an experimental system of networks of coupled non-linear chemical reactors, which we theoretically model within a reaction-diffusion framework. The networks consist of patterned arrays of diffusively coupled nanoliter-scale reactors contai...
Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy.
Lab on a chip
Jul 11, 2017
According to WHO, about 10 million new cases of thrombotic disorders are diagnosed worldwide every year. Thrombotic disorders, including atherothrombosis (the leading cause of death in the US and Europe), are induced by occlusion of blood vessels, du...
Bubble-free electrokinetic flow with propylene carbonate.
Electrophoresis
Oct 1, 2015
For electroosmotic pumping, a large direct-current (DC) electric field (10+ V/cm) is applied across a liquid, typically an aqueous electrolyte. At these high voltages, water undergoes electrolysis to form hydrogen and oxygen, generating bubbles that ...
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