AIMC Topic: Microscopy, Electron

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Automated tracing of myelinated axons and detection of the nodes of Ranvier in serial images of peripheral nerves.

Journal of microscopy Jun 12, 2015
The development of realistic neuroanatomical models of peripheral nerves for simulation purposes requires the reconstruction of the morphology of the myelinated fibres in the nerve, including their nodes of Ranvier. Currently, this information has to...
Animals Ranvier's Nodes Imaging, Three-Dimensional Peripheral Nerves Vagus Nerve Algorithms Axons Datasets as Topic Microscopy, Electron Rats Supervised Machine Learning
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Learning structured models for segmentation of 2-D and 3-D imagery.

IEEE transactions on medical imaging Nov 26, 2014
Efficient and accurate segmentation of cellular structures in microscopic data is an essential task in medical imaging. Many state-of-the-art approaches to image segmentation use structured models whose parameters must be carefully chosen for optimal...
CA1 Region, Hippocampal Models, Theoretical Mitochondria Models, Statistical Microscopy, Electron Machine Learning Algorithms Animals Imaging, Three-Dimensional
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3BTRON: A Blood-Brain Barrier Recognition Network.

Communications biology Jul 4, 2025
The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis. During ageing, the BBB undergoes structural alterations. Electron microscopy (EM) is the gold standard for studying the structural alterations of the brain vasculatu...
Male Aging Blood-Brain Barrier Animals Mice Brain Mice, Inbred C57BL Microscopy, Electron Deep Learning Image Processing, Computer-Assisted
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A guide to CNN-based dense segmentation of neuronal EM images.

Microscopy (Oxford, England) Jun 26, 2025
Large-scale reconstitution of neuronal circuits from volumetric electron microscopy images is a remarkable research goal in neuroanatomy. However, the large-scale reconstruction is a result of automatic segmentation using convolutional neural network...
Humans Neural Networks, Computer Animals Axons Microscopy, Electron Image Processing, Computer-Assisted Neurons
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Recent advancement and human tissue applications of volume electron microscopy.

Microscopy (Oxford, England) Jun 26, 2025
Structural observations are essential for the advancement of life science. Volume electron microscopy has recently realized remarkable progress in the three-dimensional analyses of biological specimens for elucidating complex ultrastructures in sever...
Humans Imaging, Three-Dimensional Microscopy, Electron Volume Electron Microscopy
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Automated cell structure extraction for 3D electron microscopy by deep learning.

Scientific reports May 20, 2025
Modeling the 3D structures of cells and tissues is crucial in biology. Sequential cross-sectional images from electron microscopy provide high-resolution intracellular structure information. The segmentation of complex cell structures remains a labor...
Image Processing, Computer-Assisted Microscopy, Electron, Scanning Deep Learning Imaging, Three-Dimensional Microscopy, Electron Rhodophyta Algorithms
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Mesoscopic structural analysis via deep learning processing, with a special reference to in vitro alteration in collagen fibre induced by a gap junction inhibitor.

Microscopy (Oxford, England) Feb 8, 2023
Dense connective tissue, including the ligament, tendon, fascia and cornea, is formed by regularly arranged collagen fibres synthesized by fibroblasts (Fbs). The mechanism by which fibre orientation is determined remains unclear. Periodontal ligament...
Periodontal Ligament Collagen Gap Junctions Microscopy, Electron Humans Deep Learning
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Instance segmentation of mitochondria in electron microscopy images with a generalist deep learning model trained on a diverse dataset.

Cell systems Jan 18, 2023
Mitochondria are extremely pleomorphic organelles. Automatically annotating each one accurately and precisely in any 2D or volume electron microscopy (EM) image is an unsolved computational challenge. Current deep learning-based approaches train mode...
Microscopy, Electron Volume Electron Microscopy Deep Learning Mitochondria
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Fear memory-associated synaptic and mitochondrial changes revealed by deep learning-based processing of electron microscopy data.

Cell reports Aug 2, 2022
Serial section electron microscopy (ssEM) can provide comprehensive 3D ultrastructural information of the brain with exceptional computational cost. Targeted reconstruction of subcellular structures from ssEM datasets is less computationally demandin...
Animals Synapses Neuronal Plasticity Microscopy, Electron Mitochondria Deep Learning Mice Fear
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Applications of deep learning in electron microscopy.

Microscopy (Oxford, England) Feb 18, 2022
We review the growing use of machine learning in electron microscopy (EM) driven in part by the availability of fast detectors operating at kiloHertz frame rates leading to large data sets that cannot be processed using manually implemented algorithm...
Algorithms Deep Learning Machine Learning Cryoelectron Microscopy Microscopy, Electron
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