Defects in pre-mRNA splicing are frequently a cause of Mendelian disease. Despite the advent of next-generation sequencing, allowing a deeper insight into a patient's variant landscape, the ability to characterize variants causing splicing defects ha...
Cancer is one of the leading cause of death, worldwide. Many believe that genomic data will enable us to better predict the survival time of these patients, which will lead to better, more personalized treatment options and patient care. As standard ...
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Nov 13, 2019
To improve the quality of MRI-based cerebral blood flow (CBF) measurements, a deep convolutional neural network (dCNN) was trained to combine single- and multi-delay arterial spin labeling (ASL) and structural images to predict gold-standard O-water ...
Small (Weinheim an der Bergstrasse, Germany)
Nov 13, 2019
Cancer is one of the leading causes of death worldwide, despite the large efforts to improve the understanding of cancer biology and development of treatments. The attempts to improve cancer treatment are limited by the complexity of the local milieu...
IEEE journal of biomedical and health informatics
Nov 11, 2019
Radiofrequency ablation (RFA) is a popular modality for tumor treatment. However, inexpensive real-time monitoring of RFA within multiple tissue types is still an ongoing research topic. The objective of this study is to utilize multi-frequency elect...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Nov 11, 2019
Yeast is one of the most widely used microbial species in the field of microbiology, and it is crucial that rapid and accurate monitoring of its process. Therefore, this study presents a method using Raman spectroscopy for quantitative analysis of ye...
Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...
Journal of chemical information and modeling
Nov 5, 2019
Adverse effects induced by drug-drug interactions may result in early termination of drug development or even withdrawal of drugs from the market, and many drug-drug interactions are caused by the inhibition of cytochrome P450 (CYP450) enzymes. There...
OBJECTIVE: Achieving accurate prediction of sepsis detection moment based on bedside monitor data in the intensive care unit (ICU). A good clinical outcome is more probable when onset is suspected and treated on time, thus early insight of sepsis ons...
Neural networks : the official journal of the International Neural Network Society
Oct 25, 2019
This paper mainly focuses on the filter design with ℓ-gain disturbance attenuation performance for a class of discrete-time positive neural networks. Discrete and distributed time-varying delays occurring in neuron transmission are taken into account...
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