Computer methods and programs in biomedicine
May 4, 2018
BACKGROUND: Computer-aided medical decision-making (CAMDM) is the method to utilize massive EMR data as both empirical and evidence support for the decision procedure of healthcare activities. Well-developed information infrastructure, such as hospit...
Prenatal screening generates a great amount of data that is used for predicting risk of various disorders. Prenatal risk assessment is based on multiple clinical variables and overall performance is defined by how well the risk algorithm is optimized...
Statistical methods in medical research
May 2, 2018
Data-adaptive methods have been proposed to estimate nuisance parameters when using doubly robust semiparametric methods for estimating marginal causal effects. However, in the presence of near practical positivity violations, these methods can produ...
Computational drug repositioning has been proven as a promising and efficient strategy for discovering new uses from existing drugs. To achieve this goal, a number of computational methods have been proposed, which are based on different data sources...
Healthcare quality is affected by various factors including trust. Patients' trust to healthcare providers is one of the most important factors for treatment outcomes. The presented study identifies optimum mixture of patient demographic features wit...
SAR and QSAR in environmental research
Apr 24, 2018
Gram-negative bacterial secreted proteins play different roles in invaded eukaryotic cells and cause various diseases. Prediction of Gram-negative bacterial secreted protein types is a meaningful and challenging task. In this paper, we develop a mult...
The aim of this report is to unveil specific prognostic factors for retroperitoneal sarcoma (RPS) patients by univariate and multivariate statistical techniques. A phase I-II study on localized RPS treated with high-dose ifosfamide and radiotherapy f...
BACKGROUND: Next generation sequencing (NGS) has become a common technology for clinical genetic tests. The quality of NGS calls varies widely and is influenced by features like reference sequence characteristics, read depth, and mapping accuracy. Wi...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 16, 2018
With increased use of electronic medical records (EMRs), data mining on medical data has great potential to improve the quality of hospital treatment and increase the survival rate of patients. Early readmission prediction enables early intervention,...
Advanced regression and machine learning models can provide personalized risk predictions to support clinical decision-making. We aimed to understand whether modeling methods impact the tendency of calibration to deteriorate as patient populations sh...