AIMC Topic: Molecular Targeted Therapy
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Computational Approaches as Rational Decision Support Systems for Discovering Next-Generation Antitubercular Agents: Mini-Review.
Current computer-aided drug design
Jan 1, 2019
Tuberculosis, malaria, dengue, chikungunya, leishmaniasis etc. are a large group of neglected tropical diseases that prevail in tropical and subtropical countries, affecting one billion people every year. Minimal funding and grants for research on th...
Recent Advances in the Machine Learning-Based Drug-Target Interaction Prediction.
Current drug metabolism
Jan 1, 2019
BACKGROUND: The identification of drug-target interactions is a crucial issue in drug discovery. In recent years, researchers have made great efforts on the drug-target interaction predictions, and developed databases, software and computational meth...
Foreword: computational special focus issue.
Future medicinal chemistry
Jul 1, 2018
Prediction of Human Drug Targets and Their Interactions Using Machine Learning Methods: Current and Future Perspectives.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2018
Identification of drug targets and drug target interactions are important steps in the drug-discovery pipeline. Successful computational prediction methods can reduce the cost and time demanded by the experimental methods. Knowledge of putative drug ...
A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.
Current pharmaceutical biotechnology
Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Some Remarks on Prediction of Drug-Target Interaction with Network Models.
Current topics in medicinal chemistry
Jan 1, 2017
System-level understanding of the relationships between drugs and targets is very important for enhancing drug research, especially for drug function repositioning. The experimental methods used to determine drug-target interactions are usually time-...
[Hepatic Resection of Multiple Liver Metastases from Gastric Cancer after Molecular Targeted Chemotherapy(S-1 plus Cisplatin plus Trastuzumab)].
Gan to kagaku ryoho. Cancer & chemotherapy
Nov 1, 2015
A 62-year-old man was diagnosed with gastric cancer and underwent distal gastrectomy, and D1+b lymph node dissection. He was diagnosed postoperatively with T1b (sm2) N0M0, Stageā
A gastric adenocarcinoma and did not receive any adjuvant chemotherapy a...
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