Neuroblastoma presents a wide variety of clinical phenotypes, demonstrating different levels of benignity and malignancy among its subtypes. Early diagnosis is essential for effective patient management. Computed tomography (CT) serves as a significa...
OBJECTIVE: To construct and select a better model based on ultrasonic-based radiomics features and clinical characteristics for prognostic subsets of pediatric neuroblastic tumors.
International journal of medical informatics
Jan 29, 2025
PURPOSE: Neuroblastoma (NB) is a childhood malignancy with a poor prognosis and a propensity for distant metastasis (DM). We aimed to establish machine learning (ML) based model to accurately predict risk of DM and prognosis of NB patients with DM.
International journal of molecular sciences
Dec 27, 2024
Neuroblastoma is a common malignant tumor in childhood that seriously endangers the health and lives of children, making it essential to find effective prognostic markers to accurately predict their clinical outcomes. The development of high-throughp...
INTRODUCTION: Cancer-associated fibroblasts (CAFs) are a diverse group of cells that significantly contribute to reshaping the tumor microenvironment (TME), and no research has systematically explored the molecular landscapes of senescence related CA...
The Explainable Modular Neural Network (XModNN) enables the identification of biomarkers, facilitating the classification of diseases and clinical parameters in transcriptomic datasets. The modules within XModNN represent specific pathways or genes o...
BACKGROUND: Due to the unique heterogeneity of neuroblastoma, its treatment and prognosis are closely related to the biological behavior of the tumor. However, the effect of the tumor immune microenvironment on neuroblastoma needs to be investigated,...
This study explores migrasomes' role in neuroblastoma, a common malignant tumor in children, and their potential impact on tumor formation. We analyzed neuroblastoma RNA-seq datasets from public databases, including GSE62564, GSE181559, target, and f...
Journal of imaging informatics in medicine
Jun 17, 2024
Two significant obstacles hinder the advancement of Radiology AI. The first is the challenge of overfitting, where small training data sets can result in unreliable outcomes. The second challenge is the need for more generalizability, the lack of whi...
Journal of cancer research and clinical oncology
Mar 21, 2024
INTRODUCTION: Accumulating evidence demonstrates that aberrant methylation of enhancers is crucial in gene expression profiles across several cancers. However, the latent effect of differently expressed enhancers between INSS stage 4S and 4 neuroblas...