AIMC Topic: Nootropic Agents

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Machine learning identifies candidates for drug repurposing in Alzheimer's disease.

Nature communications Feb 15, 2021
Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA) for another indication i...
Nerve Tissue Proteins Drug Repositioning Pharmacogenetics Neuroprotective Agents High-Throughput Screening Assays Gene Expression Regulation Cerebral Cortex Neurons Alzheimer Disease Humans Machine Learning Severity of Illness Index Gene Expression Profiling Polypharmacology Nootropic Agents Drugs, Investigational Primary Cell Culture Prescription Drugs
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Insight into potent leads for alzheimer's disease by using several artificial intelligence algorithms.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Jun 16, 2020
Several proteins including S-nitrosoglutathione reductase (GSNOR), complement Factor D, complement 3b (C3b) and Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK), have been demonstrated to be involved in pathogenesis pathways for Alzheimer's ...
Quantitative Structure-Activity Relationship Nootropic Agents Alzheimer Disease Molecular Targeted Therapy Humans Artificial Intelligence Brain Animals Plant Extracts Drug Design Molecular Docking Simulation Molecular Structure Cognition Signal Transduction Drug Discovery Molecular Dynamics Simulation Computer-Aided Design
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Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches.

Toxicological sciences : an official journal of the Society of Toxicology Jul 21, 2015
Acetylcholinesterase (AChE), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. With the increasing availability of AChE crystal structures, with or without ligan...
Peptide Mapping Insecticides Nootropic Agents Ligands Quantitative Structure-Activity Relationship Models, Molecular Imaging, Three-Dimensional Animals Binding Sites GPI-Linked Proteins Computational Biology Molecular Docking Simulation Expert Systems Databases, Protein Humans Acetylcholinesterase Nerve Tissue Proteins Artificial Intelligence Catalytic Domain Cholinesterase Inhibitors Molecular Conformation
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Optimizing Neuroprotective Nano-structured Lipid Carriers for Transdermal Delivery through Artificial Neural Network.

Pharmaceutical nanotechnology Jan 1, 2025
BACKGROUND: Dementia associated with Alzheimer's disease (AD) is a neurological disorder. AD is a progressive neurodegenerative condition that predominantly impacts the elderly population, although it can also manifest in younger people through the i...
Alzheimer Disease Nanostructures Neuroprotective Agents Drug Carriers Nootropic Agents Donepezil Memantine Administration, Cutaneous Antiparkinson Agents Humans Computer Simulation Dementia Neural Networks, Computer
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