Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological processes. Leveraging data from 2,923 proteins measured in 53,030 UK Biobank participants, we develo...
Parkinson's Disease (PD) is a deteriorating condition that mostly affects older people. The lack of conclusive treatment for PD makes diagnosis very challenging. However, using patterns like tremors for early diagnosis, handwriting analysis has becom...
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
OBJECTIVES: To explore differences in quantitative parameters of subcortical nuclei using synthetic MRI across different motor subtypes of Parkinson's Disease (PD), and to develop an interpretable model for distinguishing PD subtypes.
People with Parkinson's Disease (PD) often experience progressively worsening gait, including changes in how they turn around, as the disease progresses. Existing clinical rating tools are not capable of capturing hour-by-hour variations of PD sympto...
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Jun 18, 2025
BACKGROUND: Generative artificial intelligence (AI) in deep brain stimulation (DBS) is currently unvalidated in its content. This study sought to analyze AI responses to questions and recommendations from the 2018 Congress of Neurological Surgeons (C...
Accurate gait events detection is imperative for reliable assessment of normal and pathological gaits. However, this detection becomes challenging in the absence of force plates. Hence, this research introduces two geometric models integrated into an...
Gut microbiota has been implicated in the pathogenesis of multiple gastrointestinal (GI) and systemic metabolic and inflammatory disorders where disrupted gut microbiota composition and function (dysbiosis) has been found in multiple studies. Thus, h...
BACKGROUND: Early diagnosis of Parkinson disease remains challenging due to the current clinical diagnostic approach. With machine learning emerging as a powerful tool for biomarker discovery, we aimed to determine whether biomarkers processed by mac...
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