AIMC Topic: Paroxetine

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Influence of panic disorder and paroxetine on brain functional hubs in drug-free patients.

Journal of psychopharmacology (Oxford, England) Sep 23, 2024
BACKGROUND: The effects of panic disorder (PD) and pharmacotherapy on brain functional hubs in drug-free patients, and the utility of their degree centrality (DC) in diagnosing and predicting treatment response (TR) for PD, remained unclear.
Humans Brain Female Young Adult Adult Male Middle Aged Case-Control Studies Treatment Outcome Support Vector Machine Magnetic Resonance Imaging Paroxetine Selective Serotonin Reuptake Inhibitors Panic Disorder
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High-throughput liquid chromatography tandem mass spectrometry method for simultaneous determination of fampridine, paroxetine, and quinidine in rat plasma: Application to in vivo perfusion study.

Journal of food and drug analysis Apr 13, 2016
A selective and high-throughput liquid chromatography-mass spectrometry method has been developed and validated for the simultaneous quantification of paroxetine, fampridine, and quinidine in rat plasma using imipramine as an internal standard. Follo...
Reproducibility of Results Animals Rats Chromatography, Liquid Tandem Mass Spectrometry Paroxetine Quinidine
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Effect of Cumulative Exposure on the Efficacy of Paroxetine: A Population Pharmacokinetic-Pharmacodynamic and Machine Learning Analyses.

CPT: pharmacometrics & systems pharmacology Jun 1, 2025
Selective serotonin reuptake inhibitors (SSRIs) are widely used in depression treatment. However, the relationship between treatment efficacy and plasma concentrations remains unclear. We assessed whether the anti-depressive response can be predicted...
Humans Machine Learning Female Aged Adult Male Middle Aged Depressive Disorder, Major Treatment Outcome Area Under Curve Models, Biological Paroxetine Selective Serotonin Reuptake Inhibitors
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