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Dual high-stroke and high-work capacity artificial muscles inspired by DNA supercoiling.

Science robotics
Powering miniature robots using actuating materials that mimic skeletal muscle is attractive because conventional mechanical drive systems cannot be readily downsized. However, muscle is not the only mechanically active system in nature, and the thou...

Screening of critical variables in fabricating polycaprolactone nanoparticles using Neuro Fuzzy Logic.

International journal of pharmaceutics
In this work, we used the artificial intelligence tool known as neurofuzzy logic (NFL) for fabricating uniform nanoparticles of polycaprolactone by the nanoprecipitation method with a focus on stabilizer selection. The adaptability of NFL assisted th...

Metaheuristic Optimization-Driven Novel Deep Learning Approach for Brain Tumor Segmentation.

BioMed research international
Brain tumor has the foremost distinguished etiology of high morality. Neoplasm, a categorization of brain tumors, is very operative in distinguishing and determining the tumor's exact location in the brain. Magnetic resonance imaging (MRI) is an effi...

Predicting target-ligand interactions with graph convolutional networks for interpretable pharmaceutical discovery.

Scientific reports
Drug Discovery is an active research area that demands great investments and generates low returns due to its inherent complexity and great costs. To identify potential therapeutic candidates more effectively, we propose protein-ligand with adversari...

Deep learning with weak annotation from diagnosis reports for detection of multiple head disorders: a prospective, multicentre study.

The Lancet. Digital health
BACKGROUND: A large training dataset with high-quality annotations is necessary for building an accurate and generalisable deep learning system, which can be difficult and expensive to prepare in medical applications. We present a novel deep-learning...

Correlation between extended pelvic lymph node dissection and urinary incontinence at early phase after robot-assisted radical prostatectomy.

International journal of urology : official journal of the Japanese Urological Association
OBJECTIVES: To investigate the impact of extended pelvic lymph node dissection (ePLND) on urinary incontinence (UI) at early post-surgery robot-assisted radical prostatectomy (RARP).

PLA-GNN: Computational inference of protein subcellular location alterations under drug treatments with deep graph neural networks.

Computers in biology and medicine
The aberrant protein sorting has been observed in many conditions, including complex diseases, drug treatments, and environmental stresses. It is important to systematically identify protein mis-localization events in a given condition. Experimental ...

An explainable machine learning-based probabilistic framework for the design of scaffolds in bone tissue engineering.

Biomechanics and modeling in mechanobiology
Recently, 3D-printed biodegradable scaffolds have shown great potential for bone repair in critical-size fractures. The differentiation of the cells on a scaffold is impacted among other factors by the surface deformation of the scaffold due to mecha...

Physics-Informed Deep Learning Approach for Reintroducing Atomic Detail in Coarse-Grained Configurations of Multiple Poly(lactic acid) Stereoisomers.

Journal of chemical information and modeling
Multiscale modeling of complex molecular systems, such as macromolecules, encompasses methods that combine information from fine and coarse representations of molecules to capture material properties over a wide range of spatiotemporal scales. Being ...