AIMC Topic: Precision Medicine

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Can Machine Learning Personalize Cardiovascular Therapy in Sepsis?

Critical care explorations
Large randomized trials in sepsis have generally failed to find effective novel treatments. This is increasingly attributed to patient heterogeneity, including heterogeneous cardiovascular changes in septic shock. We discuss the potential for machine...

Learning with an evolving medicine label: how artificial intelligence-based medication recommendation systems must adapt to changing medication labels.

Expert opinion on drug safety
INTRODUCTION: Artificial intelligence or machine learning (AI/ML) based systems can help personalize prescribing decisions for individual patients. The recommendations of these clinical decision support systems must relate to the "label" of the medic...

Determining individual suitability for neoadjuvant systemic therapy in breast cancer patients through deep learning.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
BACKGROUND: The survival advantage of neoadjuvant systemic therapy (NST) for breast cancer patients remains controversial, especially when considering the heterogeneous characteristics of individual patients.

Personalised prediction of maintenance dialysis initiation in patients with chronic kidney disease stages 3-5: a multicentre study using the machine learning approach.

BMJ health & care informatics
BACKGROUND: Optimal timing for initiating maintenance dialysis in patients with chronic kidney disease (CKD) stages 3-5 is challenging. This study aimed to develop and validate a machine learning (ML) model for early personalised prediction of mainte...

An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma.

Nature communications
Pediatric papillary thyroid carcinomas (PPTCs) exhibit high inter-tumor heterogeneity and currently lack widely adopted recurrence risk stratification criteria. Hence, we propose a machine learning-based objective method to individually predict their...

Artificial Intelligence-Driven Radiomics in Head and Neck Cancer: Current Status and Future Prospects.

International journal of medical informatics
BACKGROUND: Radiomics is a rapidly growing field used to leverage medical radiological images by extracting quantitative features. These are supposed to characterize a patient's phenotype, and when combined with artificial intelligence techniques, to...

Precision medicine in colorectal cancer: Leveraging multi-omics, spatial omics, and artificial intelligence.

Clinica chimica acta; international journal of clinical chemistry
Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Recent advancements in genomic technologies and analytical approaches have revolutionized CRC research, enabling precision medicine. This review highlights the integration of multi-...

[The revolution of AI in drug development].

Medecine sciences : M/S
Artificial intelligence and machine learning enable the construction of predictive models, which are currently used to assist in decision-making throughout the process of drug discovery and development. These computational models can be used to repre...

AI-driven design of customized 3D-printed multi-layer capsules with controlled drug release profiles for personalized medicine.

International journal of pharmaceutics
Personalized medicine aims to effectively and efficiently provide customized drugs that cater to diverse populations, which is a significant yet challenging task. Recently, the integration of artificial intelligence (AI) and three-dimensional (3D) pr...