AIMC Topic: Pyrroles

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Parallel Signal Processing of a Wireless Pressure-Sensing Platform Combined with Machine-Learning-Based Cognition, Inspired by the Human Somatosensory System.

Advanced materials (Deerfield Beach, Fla.) Dec 16, 2019
Inspired by the human somatosensory system, pressure applied to multiple pressure sensors is received in parallel and combined into a representative signal pattern, which is subsequently processed using machine learning. The pressure signals are comb...
Wearable Electronic Devices Polymers Humans Machine Learning Pressure Pyrroles Wireless Technology Electrodes Dimethylpolysiloxanes
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Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

European journal of medicinal chemistry Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Haplorhini Pyrroles Protein-Tyrosine Kinases Pyrimidines Arthritis, Rheumatoid Structure-Activity Relationship Agammaglobulinaemia Tyrosine Kinase Rats Cell Proliferation Dose-Response Relationship, Drug Rats, Sprague-Dawley Dogs Cell Line Drug Design Humans Microsomes, Liver Models, Molecular Mice Animals Protein Kinase Inhibitors Molecular Structure
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Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study.

Pediatric rheumatology online journal Dec 28, 2017
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in pati...
Humans Female Adolescent Child, Preschool Male Arthritis, Juvenile Piperidines Pyrimidines Pyrroles Protein Kinase Inhibitors Administration, Oral Taste Child Treatment Outcome
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Spectrophotometric determination of fluoxetine by molecularly imprinted polypyrrole and optimization by experimental design, artificial neural network and genetic algorithm.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Sep 13, 2017
A selective method based on molecularly imprinted polymer (MIP) solid-phase extraction (SPE) using UV-Vis spectrophotometry as a detection technique was developed for the determination of fluoxetine (FLU) in pharmaceutical and human serum samples. Th...
Neural Networks, Computer Algorithms Reference Standards Spectrophotometry Solutions Fluoxetine Pyrroles Molecular Imprinting Calibration Regression Analysis Polymers
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Protective coatings for intraocular wirelessly controlled microrobots for implantation: Corrosion, cell culture, and in vivo animal tests.

Journal of biomedical materials research. Part B, Applied biomaterials Jan 24, 2016
Diseases in the ocular posterior segment are a leading cause of blindness. The surgical skills required to treat them are at the limits of human manipulation ability, and involve the risk of permanent retinal damage. Instrument tethering and design l...
Coated Materials, Biocompatible Injections, Intraocular Materials Testing NIH 3T3 Cells Implants, Experimental Pyrroles Wireless Technology Gold Nickel Rabbits Cobalt Polymers Mice Robotics Female Animals
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