BACKGROUND: Whole brain radiotherapy (WBRT) can impair patients' cognitive function. Hippocampal avoidance during WBRT can potentially prevent this side effect. However, manually delineating the target area is time-consuming and difficult. Here, we p...
Journal of applied clinical medical physics
Jan 7, 2021
PURPOSE: To evaluate the dosimetric and image-guided radiation therapy (IGRT) performance of a novel generative adversarial network (GAN) generated synthetic CT (synCT) in the brain and compare its performance for clinical use including conventional ...
Accurate and efficient dose calculation is an important prerequisite to ensure the success of radiation therapy. However, all the dose calculation algorithms commonly used in current clinical practice have to compromise between calculation accuracy a...
To study radiotherapy-related adverse effects, detailed dose information (3D distribution) is needed for accurate dose-effect modeling. For childhood cancer survivors who underwent radiotherapy in the pre-CT era, only 2D radiographs were acquired, th...
Cone-beam computed tomography (CBCT)- and magnetic resonance (MR)-images allow a daily observation of patient anatomy but are not directly suited for accurate proton dose calculations. This can be overcome by creating synthetic CTs (sCT) using deep c...
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Nov 29, 2020
OBJECTIVE: Dose prediction using deep learning networks prior to radiotherapy might lead tomore efficient modality selections. The study goal was to predict proton and photon dose distributions based on the patient-specific anatomy and to assess thei...
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Nov 29, 2020
BACKGROUND AND PURPOSE: Comprehensive dosimetric analysis is required prior to the clinical implementation of pelvic MR-only sites, other than prostate, due to the limited number of site specific synthetic-CT (sCT) dosimetric assessments in the liter...
We developed a fluence map prediction method that directly generates fluence maps for a given desired dose distribution without optimization for volumetric modulated arc therapy (VMAT) planning. The prediction consists of two steps. First, projection...
International journal of radiation oncology, biology, physics
Nov 13, 2020
PURPOSE: Contouring inconsistencies are known but understudied in clinical radiation therapy trials. We applied auto-contouring to the Radiation Therapy Oncology Group (RTOG) 0617 dose escalation trial data. We hypothesized that the trial heart doses...
International journal of radiation oncology, biology, physics
Nov 13, 2020
PURPOSE: Our purpose was to assess the use of machine learning methods and Mobius 3D (M3D) dose calculation software to reduce the number of physical ion chamber (IC) dose measurements required for patient-specific quality assurance during corona vir...
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