AIMC Topic: Receptor Protein-Tyrosine Kinases

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Exploratory drug discovery in breast cancer patients: A multimodal deep learning approach to identify novel drug candidates targeting RTK signaling.

Computers in biology and medicine Apr 16, 2024
Breast cancer, a highly formidable and diverse malignancy predominantly affecting women globally, poses a significant threat due to its intricate genetic variability, rendering it challenging to diagnose accurately. Various therapies such as immunoth...
Humans Female Breast Neoplasms Drug Discovery Antineoplastic Agents Deep Learning Signal Transduction Quantitative Structure-Activity Relationship Protein Kinase Inhibitors Receptor Protein-Tyrosine Kinases
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SEA-NET: medical image segmentation network based on spiral squeeze-and-excitation and attention modules.

BMC medical imaging Jan 11, 2024
BACKGROUND: Medical image segmentation is an important processing step in most of medical image analysis. Thus, high accuracy and robustness are required for them. The current deep neural network based medical segmentation methods have good effect on...
Humans Neural Networks, Computer Image Processing, Computer-Assisted Semantics Neuroimaging Entropy Receptor Protein-Tyrosine Kinases
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COVID-19 infection segmentation using hybrid deep learning and image processing techniques.

Scientific reports Dec 20, 2023
The coronavirus disease 2019 (COVID-19) epidemic has become a worldwide problem that continues to affect people's lives daily, and the early diagnosis of COVID-19 has a critical importance on the treatment of infected patients for medical and healthc...
Humans COVID-19 Tomography, X-Ray Computed SARS-CoV-2 Deep Learning Image Processing, Computer-Assisted Receptor Protein-Tyrosine Kinases
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RTK_RAG: Leveraging Retrieval Augmented Generation with Multi-Window Convolutional Neural Networks for Superior ATP Binding Site Prediction in Receptor Tyrosine Kinases.

Journal of chemical information and modeling Jul 14, 2025
Receptor tyrosine kinases (RTKs) are key regulators of cellular signaling and are frequently involved in cancer development. As their activation depends on ATP binding to the kinase domain, precisely identifying ATP binding sites is critical for mech...
Humans Neural Networks, Computer Convolutional Neural Networks Adenosine Triphosphate Binding Sites Receptor Protein-Tyrosine Kinases
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Clinical significance of hepatic function in Graves disease with type 2 diabetic mellitus: A single-center retrospective cross-sectional study in Taiwan.

Medicine Aug 26, 2022
Graves disease (GD) and type 2 diabetes mellitus (T2DM) both impair liver function; we therefore explored the possibility of a relationship among diabetic control, thyroid function, and liver function. This retrospective, cross-sectional study compar...
Humans Biomarkers Retrospective Studies Cross-Sectional Studies Diabetes Mellitus, Type 2 Taiwan Thyrotropin Glycated Hemoglobin Thyroxine Graves Disease Triiodothyronine Alanine Transaminase Aspartate Aminotransferases Glutamates Receptor Protein-Tyrosine Kinases
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