International journal of molecular sciences
Mar 3, 2015
Protein-protein interaction (PPI) is essential for almost all cellular processes and identification of PPI is a crucial task for biomedical researchers. So far, most computational studies of PPI are intended for pair-wise prediction. Theoretically, p...
Clinical cancer research : an official journal of the American Association for Cancer Research
Jan 16, 2026
PURPOSE: Despite current standard-of-care endocrine therapy, distant recurrence remains a concern for patients with hormone receptor-positive (HR+)/HER2- early breast cancer (EBC). Understanding individual recurrence risk would aid in clinical decisi...
UNLABELLED: The standard approach of using one-size-fits-all endocrine therapy for hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancers has faced significant challenges because of variations in tr...
The absence of effective public databases greatly limits high-throughput prediction of hormonal effects mediated by nuclear receptors in aquatic organisms. In this study, we developed novel strategies for multi-species screening of estrogen receptor ...
PURPOSE: Gene expression profiles are used for decision making in the adjuvant setting in hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer. While algorithms to optimize testing exist for RS/Oncotype Dx, no such efforts have focused ...
Approximately 70% of breast cancer (BC) diagnoses are estrogen receptor positive (ER) with ∼40% of ER BC patients presenting resistance to endocrine therapy (ET). Recent studies identify the tumor microenvironment (TME) as having a key role in endoc...
Breast cancer liver metastasis (BCLM) presents a critical challenge in breast cancer treatment and has substantial epidemiological and clinical significance. Receptor status is pivotal in managing both primary breast cancer and its liver metastases. ...
BACKGROUND: Biomarkers of angiogenesis and lymphangiogenesis have been explored in cancer prognostic models; however, their potential role in assessing local tumor invasiveness remains poorly understood.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Mar 1, 2023
Image analysis assistance with artificial intelligence (AI) has become one of the great promises over recent years in pathology, with many scientific studies being published each year. Nonetheless, and perhaps surprisingly, only few image AI systems ...
BACKGROUND: Drug discovery requires the use of hybrid technologies for the discovery of new chemical substances. One of those interesting strategies is QSAR via applying an artificial intelligence system that effectively predicts how chemical alterat...
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