AIMC Topic: Research Design

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Exploring tuberculosis patients' preferences for AI-assisted remote health management services in China: a protocol for a discrete choice experiment.

BMJ open
INTRODUCTION: Effective health management is critical for patients with tuberculosis (TB), especially given the need for long-term treatment adherence and continuous monitoring. Artificial intelligence (AI)-assisted remote health management services ...

Methodological conduct and risk of bias in studies on prenatal birthweight prediction models using machine learning techniques: a systematic review.

BMC pregnancy and childbirth
OBJECTIVE: To assess the methodological quality and the risk of bias, of studies that developed prediction models using Machine Learning (ML) techniques to estimate prenatal birthweight.

Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis.

BMJ open
INTRODUCTION: The WHO's Integrated Management of Childhood Illness (IMCI) in young infants <2 months of age includes the identification and management of signs of possible serious bacterial infection (PSBI). However, equal importance is given to all ...

Study protocol for the Rainbow Austrian Longitudinal Family (RALF) study: a longitudinal, multi-method, multi-rater investigation of risk and resilience factors in Austrian LGBTQ+ parent families.

BMC psychology
BACKGROUND: Research on LGBTQ+ parent families is evolving to include a growing range of family systems, identities, methodologies, and topics. However, studies that examine minority-specific risk and resilience factors and their associations with wi...

Characterising physical activity patterns in community-dwelling older adults using digital phenotyping: a 2-week observational study protocol.

BMJ open
INTRODUCTION: Physical activity (PA) is crucial for older adults' well-being and mitigating health risks. Encouraging active lifestyles requires a deeper understanding of the factors influencing PA, which conventional approaches often overlook by ass...

Using Large Language Models for Advanced and Flexible Labelling of Protocol Deviations in Clinical Development.

Therapeutic innovation & regulatory science
BACKGROUND: As described in ICH E3 Q&A R1 (International Council for Harmonisation. E3: Structure and content of clinical study reports-questions and answers (R1). 6 July 2012. Available from: https://database.ich.org/sites/default/files/E3_Q%26As_R1...

Enriching patient populations in ICU trials: reducing heterogeneity through machine learning.

Current opinion in critical care
PURPOSE OF REVIEW: Despite the pivotal role of randomized controlled trials (RCTs) in critical care research, many have failed to demonstrate significant benefits, particularly in nutrition interventions. This review highlights how patient heterogene...

The role of artificial intelligence in the prediction, identification, diagnosis and treatment of perinatal depression and anxiety among women in LMICs: a systematic review protocol.

BMJ open
INTRODUCTION: Perinatal depression and anxiety (PDA) is associated with a high risk of maternal mortality. Existing data shows that 95% of maternal mortality in low- and middle-income countries (LMICs) is due to resource constraints and negligence in...

Designing Clinical Trials for Patients With Rare Cancers: Connecting the Zebras.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
The field of rare cancer research is rapidly transforming, marked by significant progress in clinical trials and treatment strategies. Rare cancers, as defined by the National Cancer Institute, occur in fewer than 150 cases per million people each ye...