AIMC Topic: RNA, Long Noncoding

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Construction of Immune Infiltration-Related LncRNA Signatures Based on Machine Learning for the Prognosis in Colon Cancer.

Biochemical genetics Oct 4, 2023
Colon cancer is one of the malignant tumors with high morbidity, lethality, and prevalence across global human health. Molecular biomarkers play key roles in its prognosis. In particular, immune-related lncRNAs (IRL) have attracted enormous interest ...
Biomarkers, Tumor Male Prognosis Female RNA, Long Noncoding Colonic Neoplasms Gene Expression Regulation, Neoplastic Nomograms Humans Machine Learning
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Predicting Plant miRNA-lncRNA Interactions via a Deep Learning Method.

IEEE transactions on nanobioscience Oct 3, 2023
In recent years, due to the contribution to elucidating the functional mechanisms of miRNAs and lncRNAs, the research on miRNA-lncRNA interaction prediction has increased exponentially. However, the prediction research is challenging in bioinformatic...
RNA, Long Noncoding Arabidopsis Computational Biology Animals MicroRNAs Deep Learning
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DeepdlncUD: Predicting regulation types of small molecule inhibitors on modulating lncRNA expression by deep learning.

Computers in biology and medicine Jul 1, 2023
Targeting lncRNAs by small molecules (SM-lncR) to alter their expression levels has emerged as an important therapeutic modality for disease treatment. To date, no computational tools have been dedicated to predicting small molecule-mediated upregula...
Computational Biology RNA, Long Noncoding Algorithms Deep Learning
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Deep Learning Approaches for lncRNA-Mediated Mechanisms: A Comprehensive Review of Recent Developments.

International journal of molecular sciences Jun 18, 2023
This review paper provides an extensive analysis of the rapidly evolving convergence of deep learning and long non-coding RNAs (lncRNAs). Considering the recent advancements in deep learning and the increasing recognition of lncRNAs as crucial compon...
Computational Biology RNA, Long Noncoding Deep Learning
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An Optimized Ensemble Deep Learning Model for Predicting Plant miRNA-IncRNA Based on Artificial Gorilla Troops Algorithm.

Sensors (Basel, Switzerland) Feb 16, 2023
MicroRNAs (miRNA) are small, non-coding regulatory molecules whose effective alteration might result in abnormal gene manifestation in the downstream pathway of their target. miRNA gene variants can impact miRNA transcription, maturation, or target s...
Plant Physiological Phenomena Animals Deep Learning MicroRNAs RNA, Long Noncoding Algorithms Reproducibility of Results Humans
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Finding lncRNA-Protein Interactions Based on Deep Learning With Dual-Net Neural Architecture.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2022
The identification of lncRNA-protein interactions (LPIs) is important to understand the biological functions and molecular mechanisms of lncRNAs. However, most computational models are evaluated on a unique dataset, thereby resulting in prediction bi...
RNA, Long Noncoding Deep Learning Computational Biology
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DeepPlnc: Bi-modal deep learning for highly accurate plant lncRNA discovery.

Genomics Aug 2, 2022
We present here a bi-modal CNN based deep-learning system, DeepPlnc, to identify plant lncRNAs with high accuracy while using sequence and structural properties. Unlike most of the existing software, it works accurately even in conditions with ambigu...
Plants Molecular Sequence Annotation Software Deep Learning Transcriptome RNA, Long Noncoding
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MD-MLI: Prediction of miRNA-lncRNA Interaction by Using Multiple Features and Hierarchical Deep Learning.

IEEE/ACM transactions on computational biology and bioinformatics Jun 3, 2022
Long non-coding RNA(lncRNA) can interact with microRNA(miRNA) and play an important role in inhibiting or activating the expression of target genes and the occurrence and development of tumors. Accumulating studies focus on the prediction of miRNA-ln...
Machine Learning RNA, Long Noncoding Deep Learning Computational Biology MicroRNAs Humans
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LDICDL: LncRNA-Disease Association Identification Based on Collaborative Deep Learning.

IEEE/ACM transactions on computational biology and bioinformatics Jun 3, 2022
It has been proved that long noncoding RNA (lncRNA) plays critical roles in many human diseases. Therefore, inferring associations between lncRNAs and diseases can contribute to disease diagnosis, prognosis and treatment. To overcome the limitation o...
Algorithms Deep Learning Computational Biology RNA, Long Noncoding Humans
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Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer.

Nature communications Feb 10, 2022
Long noncoding RNAs (lncRNAs) are recently implicated in modifying immunology in colorectal cancer (CRC). Nevertheless, the clinical significance of immune-related lncRNAs remains largely unexplored. In this study, we develope a machine learning-base...
Biomarkers, Tumor Risk Factors Fluorouracil Humans B7-H1 Antigen Chemotherapy, Adjuvant Colorectal Neoplasms Gene Expression Profiling Machine Learning Gene Expression Regulation, Neoplastic CD8 Antigens RNA, Long Noncoding Neoplasm Recurrence, Local
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