AIMC Topic: Semaphorins

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ceRNA regulatory network and immune-neurodegenerative mechanisms of peripheral CD4+ T cells in parkinson's disease.

PloS one Dec 2, 2025
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and neuroinflammation, with emerging roles of peripheral immune dysregulation in disease progression. This study aimed to investigate the regulatory ne...
Humans Female Aged Male Middle Aged Gene Expression Profiling Case-Control Studies Gene Regulatory Networks RNA, Messenger Parkinson Disease MicroRNAs RNA, Long Noncoding CD4-Positive T-Lymphocytes Semaphorins RNA, Competitive Endogenous
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Identifying semaphorin 3C as a biomarker for sarcopenia and coronary artery disease via bioinformatics and machine learning.

Archives of gerontology and geriatrics Jan 15, 2025
OBJECTIVE: Sarcopenia not only affects patients' quality of life but also may exacerbate the pathological processes of coronary artery disease (CAD). This study aimed to identify potential biomarkers to improve the combined diagnosis and treatment of...
Humans Machine Learning Biomarkers Aged Male ROC Curve Computational Biology Sarcopenia Mendelian Randomization Analysis Coronary Artery Disease Semaphorins
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Prediction Power on Cardiovascular Disease of Neuroimmune Guidance Cues Expression by Peripheral Blood Monocytes Determined by Machine-Learning Methods.

International journal of molecular sciences Sep 2, 2020
Atherosclerosis is the underlying pathology in a major part of cardiovascular disease, the leading cause of mortality in developed countries. The infiltration of monocytes into the vessel walls of large arteries is a key denominator of atherogenesis,...
Humans Machine Learning Biomarkers Female Adult Male Cardiovascular Diseases Middle Aged Transcriptome Case-Control Studies Cohort Studies Monocytes Ephrins Netrin-1 Semaphorins
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