Biochemical and biophysical research communications
Oct 4, 2025
The extracellular matrix (ECM) is crucial in tuning cellular behavior, and quantifying cellular mechanical changes in response to ECM stimuli can help reveal the underlying physical mechanisms of cell-ECM interactions for a comprehensive understandin...
BACKGROUND: Single-cell foundation models (scFMs) have emerged as powerful tools for integrating heterogeneous datasets and exploring biological systems. Despite high expectations, their ability to extract unique biological insights beyond standard m...
Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous tumor that lacks reliable biological markers for diagnosis and prognostic monitoring. Currently, the differentially expressed genes between paired adjacent normal tissues and ccRCC tum...
The development of the immune system (ISD) plays a pivotal role in both the genesis and progression of tumors, yet its specific functions in hepatocellular carcinoma (HCC) and the mechanisms behind sorafenib resistance remain elusive. In our investig...
Tumor heterogeneity poses a major challenge to the precision treatment of medulloblastoma (MB). Rapid and accurate subtyping tools are urgently needed for informed clinical decision-making. Herein, we demonstrate the utility of Raman spectroscopy (RS...
Lymph node (LN) lymphatic endothelial cells (LEC) actively acquire and archive foreign antigens. Here, we address questions of how LECs achieve durable antigen archiving and whether LECs with high levels of antigen express unique transcriptional prog...
BACKGROUND: Immunogenic cell death (ICD) triggers antitumor immune responses and plays a critical role in shaping the tumor microenvironment (TME). However, its specific contribution to lung adenocarcinoma (LUAD) progression and immunotherapy respons...
BACKGROUND: Analysis of single-cell RNA sequencing (scRNA-seq) data has revolutionized our understanding of cellular heterogeneity, yet current approaches face challenges in efficiency, interpretability, and connecting molecular insights to therapeut...
Colorectal cancer (CRC) remains a major global health burden with high mortality rates, underscoring the need for effective therapies. This study explores the acetylation characteristics in CRC using single-cell RNA sequencing (scRNA-seq) and weighte...
Partitioning cells in open nanowells permits high confidence in single cell occupancy and enables flexibility in the development of different molecular assays. A challenge for this approach however is to print cells sufficiently quickly to enable exp...
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