AIMC Topic:
Software
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Feature selection and tumor classification for microarray data using relaxed Lasso and generalized multi-class support vector machine.
Journal of theoretical biology
Dec 8, 2018
At present, the study of gene expression data provides a reference for tumor diagnosis at the molecular level. It is a challenging task to select the feature genes related to the classification from the high-dimensional and small-sample gene expressi...
GOnet: a tool for interactive Gene Ontology analysis.
BMC bioinformatics
Dec 7, 2018
BACKGROUND: Biological interpretation of gene/protein lists resulting from -omics experiments can be a complex task. A common approach consists of reviewing Gene Ontology (GO) annotations for entries in such lists and searching for enrichment pattern...
Artificial intelligence and computer-aided diagnosis in colonoscopy: current evidence and future directions.
The lancet. Gastroenterology & hepatology
Dec 6, 2018
Computer-aided diagnosis offers a promising solution to reduce variation in colonoscopy performance. Pooled miss rates for polyps are as high as 22%, and associated interval colorectal cancers after colonoscopy are of concern. Optical biopsy, whereby...
Neural network analysis of Chinese herbal medicine prescriptions for patients with colorectal cancer.
Complementary therapies in medicine
Dec 5, 2018
Traditional Chinese Medicine (TCM) is an experiential form of medicine with a history dating back thousands of years. The present study aimed to utilize neural network analysis to examine specific prescriptions for colorectal cancer (CRC) in clinical...
Deep Convolutional Neural Networks for the Prediction of Molecular Properties: Challenges and Opportunities Connected to the Data.
Journal of integrative bioinformatics
Dec 5, 2018
We present a flexible deep convolutional neural network method for the analysis of arbitrary sized graph structures representing molecules. This method, which makes use of the Lipinski RDKit module, an open-source cheminformatics software, enables th...
Selecting Test Cases from the Electronic Health Record for Software Testing of Knowledge-Based Clinical Decision Support Systems.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Software testing of knowledge-based clinical decision support systems is challenging, labor intensive, and expensive; yet, testing is necessary since clinical applications have heightened consequences. Thoughtful test case selection improves testing ...
A Primer on Data Analytics in Functional Genomics: How to Move from Data to Insight?
Trends in biochemical sciences
Dec 3, 2018
High-throughput methodologies and machine learning have been central in developing systems-level perspectives in molecular biology. Unfortunately, performing such integrative analyses has traditionally been reserved for bioinformaticians. This is now...
BetaDL: A protein beta-sheet predictor utilizing a deep learning model and independent set solution.
Computers in biology and medicine
Dec 2, 2018
The sequence-based prediction of beta-residue contacts and beta-sheet structures contain key information for protein structure prediction. However, the determination of beta-sheet structures poses numerous challenges due to long-range beta-residue in...
Organic synthesis in a modular robotic system driven by a chemical programming language.
Science (New York, N.Y.)
Nov 29, 2018
The synthesis of complex organic compounds is largely a manual process that is often incompletely documented. To address these shortcomings, we developed an abstraction that maps commonly reported methodological instructions into discrete steps amena...
Versatility of fuzzy logic in chronic diseases: A review.
Medical hypotheses
Nov 27, 2018
The review aims at providing current state of evidence in the field of medicine with fuzzy logic for diagnosing diseases. Literature reveals that fuzzy logic has been used effectively in medicine. Different types of methodologies have been applied to...
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