AIMC Topic: Sphingosine

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Metabolomics and machine learning approaches for diagnostic biomarkers screening in systemic light chain amyloidosis.

Annals of hematology Mar 13, 2025
Delayed diagnosis of systemic light chain (AL) amyloidosis is common and associated with worse survival and early mortality. Current diagnosis still relies on invasive tissue biopsies, highlighting the need for sensitive, noninvasive biomarkers for e...
Humans Machine Learning Biomarkers Female Aged Adult Male Middle Aged Sphingosine Metabolomics Multiple Myeloma Immunoglobulin Light-chain Amyloidosis
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Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer.

Pathology oncology research : POR Jan 6, 2025
OBJECTIVES: Spingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circulating ...
Humans Prognosis Female Aged Adult Biomarkers, Tumor Male Middle Aged Case-Control Studies Lung Neoplasms Carcinoma, Non-Small-Cell Lung Ceramides Sphingosine Lysophospholipids Follow-Up Studies
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Clinical correlations of plasma sphingosine-1-phosphate and sphingolipid key enzymes in severe dengue using laboratory and machine learning approach.

Clinica chimica acta; international journal of clinical chemistry Jun 15, 2025
BACKGROUND: Sphingolipids are crucial for vascular integrity and cellular homeostasis, with recent studies highlighting their role in viral diseases.
Humans Machine Learning Prospective Studies Female Young Adult Adult Male Middle Aged Adolescent Sphingosine Lysophospholipids Sphingolipids Severe Dengue
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