AIMC Topic: Syringes
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Loss of micropollutants on syringe filters during sample filtration: Machine learning approach for selecting appropriate filters.
Chemosphere
May 14, 2024
Prefiltration before chromatographic analysis is critical in the monitoring of environmental micropollutants (MPs). However, in an aqueous matrix, such monitoring often leads to out-of-specification results owing to the loss of MPs on syringe filters...
Advanced Characterization of Silicone Oil Droplets in Protein Therapeutics Using Artificial Intelligence Analysis of Imaging Flow Cytometry Data.
Journal of pharmaceutical sciences
Jul 14, 2020
Monitoring protein particles is increasingly emphasized in the development of biopharmaceuticals due to potential immunogenicity. Accurate quantitation of protein particles is complicated by silicone oil droplets, a common pharmaceutical component in...
Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations.
Science advances
Jul 8, 2020
Inefficient injection of microparticles through conventional hypodermic needles can impose serious challenges on clinical translation of biopharmaceutical drugs and microparticle-based drug formulations. This study aims to determine the important fac...
Physicochemical stability of an admixture of lidocaine and ketamine in polypropylene syringe used in opioid-free anaesthesia.
European journal of hospital pharmacy : science and practice
Oct 18, 2019
OBJECTIVES: Opioid-free anaesthesia is a treatment strategy of pain management based on the use of drugs such as lidocaine, ketamine and dexmedetomidine that do not interact significantly with opioid receptors. In particular, these drugs are used by ...
Physicochemical stability of nefopam and nefopam/droperidol solutions in polypropylene syringes for intensive care units.
European journal of hospital pharmacy : science and practice
Jun 11, 2019
INTRODUCTION: Nefopam has been reported to be effective in postoperative pain control with an opioid-sparing effect, but the use of nefopam can lead to nausea and vomiting. To prevent these side effects, droperidol can be mixed with nefopam. In inten...
Qualification of a chemotherapy-compounding robot.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Apr 18, 2019
KIRO® Oncology (Kiro Grifols, Spain) is a robotic system for automated compounding of sterile injectable drugs including intravenous cytotoxic treatments. The present article describes the qualification procedure applied prior to production phases. P...
Stability of sodium bicarbonate injection 8.4% in syringes over a six-week period in refrigerated temperature.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Feb 20, 2017
Background Dysfunctional central venous catheter prohibits the administration of potential life-saving chemotherapy and the delivery of essential supportive care needs to patients. Sodium bicarbonate injection has been shown to impede against fibrin ...
Analytical approach to determining human biogenic amines and their metabolites using eVol microextraction in packed syringe coupled to liquid chromatography mass spectrometry method with hydrophilic interaction chromatography column.
Talanta
Dec 21, 2015
Analysis of biogenic amines (BAs) in different human samples provides insight into the mechanisms of various biological processes, including pathological conditions, and thus may be very important in diagnosing and monitoring several neurological dis...
Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects.
Clinical pharmacology in drug development
Dec 4, 2015
Intravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self-administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose o...
Media-fill simulation tests in manual and robotic aseptic preparation of injection solutions in syringes.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Dec 30, 2014
OBJECTIVE: The purpose of this study was to evaluate the contamination rate of media-fill products either prepared automated with a robotic system (APOTECAchemo™) or prepared manually at cytotoxic workbenches in the same cleanroom environment and by ...
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