AIMC Topic: Isoproterenol

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Automated phenotypic analysis and classification of drug-treated cardiomyocytes via synergized time-lapse holographic imaging and deep learning.

Computer methods and programs in biomedicine Jun 4, 2025
BACKGROUND AND OBJECTIVE: Predicting cardiovascular risk is critical for the therapy and control of cardiovascular illnesses. This work studies screening the toxicity of three drugs, (E-4031, isoprenaline, and sertindole) with various concentrations ...
Humans Algorithms Phenotype Deep Learning Pyridines Piperidines Isoproterenol Myocytes, Cardiac Holography Induced Pluripotent Stem Cells Time-Lapse Imaging
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Detection of biomagnetic signals from induced pluripotent stem cell-derived cardiomyocytes using deep learning with simulation data.

Scientific reports Mar 27, 2024
The detection of spontaneous magnetic signals can be used for the non-invasive electrophysiological evaluation of induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs). We report that deep learning with a dataset that combines magnetic signa...
Animals Deep Learning Mice Cell Differentiation Drug Evaluation, Preclinical Isoproterenol Myocytes, Cardiac Induced Pluripotent Stem Cells
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Using machine learning to model dose-response relationships.

Journal of evaluation in clinical practice May 30, 2016
RATIONALE, AIMS AND OBJECTIVES: Establishing the relationship between various doses of an exposure and a response variable is integral to many studies in health care. Linear parametric models, widely used for estimating dose-response relationships, h...
Humans Machine Learning Algorithms Male Dose-Response Relationship, Drug Discriminant Analysis Data Mining Isoproterenol Blood Flow Velocity Cardiotonic Agents
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aqueous extract attenuates isoproterenol-induced cardiac hypertrophy through the ERK signalling pathway.

Pharmaceutical biology Dec 1, 2020
CONTEXT: The pharmacological functions of Wall. ex Lindl. (Orchidaceae) in cardiac hypertrophy remains unclear.
Female Animals Male Plant Extracts Rats Signal Transduction Rats, Sprague-Dawley Cell Line Myocardium Heart Cardiomegaly Fibrosis Dendrobium Isoproterenol MAP Kinase Signaling System Myoblasts Myocytes, Cardiac
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