AIMC Topic: Transcription Factor AP-1

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Diagnostic immune-related markers for diabetic kidney disease: a bioinformatics and machine learning approach.

Renal failure Jul 10, 2025
OBJECTIVE: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease, with chronic inflammation driving its progression. This study aimed to identify immune-related diagnostic biomarkers for DKD and explore their association with imm...
Humans Machine Learning Biomarkers Animals Male Gene Expression Profiling Transcriptome Protein Interaction Maps Mice Diabetic Nephropathies Computational Biology Kidney Glomerulus Proto-Oncogene Proteins c-fos Transcription Factor AP-1
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Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer.

Genome research Jun 25, 2024
Gastric cancer (GC) is the fifth most common cancer worldwide and is a heterogeneous disease. Among GC subtypes, the mesenchymal phenotype (Mes-like) is more invasive than the epithelial phenotype (Epi-like). Although gene expression of the epithelia...
Humans Machine Learning Stomach Neoplasms Cell Line, Tumor Gene Expression Regulation, Neoplastic DNA Copy Number Variations Core Binding Factor Alpha 1 Subunit Epithelial-Mesenchymal Transition Fibrosis Transcription Factor AP-1 Core Binding Factor Alpha 2 Subunit
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