AIMC Topic: Ubiquitin-Protein Ligases

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Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Nucleic acids research Dec 1, 2017
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety...
Humans Neural Networks, Computer Machine Learning Sequence Analysis, RNA Epigenesis, Genetic Cell Line Cell Differentiation High-Throughput Nucleotide Sequencing Tumor Suppressor Proteins Ubiquitin-Protein Ligases Cell Lineage Alternative Splicing Embryonic Stem Cells Histone Code
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[Apple polyphenol inhibited the proliferation and migration of breast cancer cell MDA-MB-231 mediated by UHRF1].

Wei sheng yan jiu = Journal of hygiene research Nov 1, 2017
OBJECTIVE: To investigate the effects of apple polyphenol on cell proliferation and migration of breast cancer cell line MDA-MB-231, and explore the potential mechanism.
Humans Female Breast Neoplasms Cell Line, Tumor Cell Proliferation Cell Movement Flavonoids Tannins Chlorogenic Acid CCAAT-Enhancer-Binding Proteins Malus Ubiquitin-Protein Ligases
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