AIMC Topic: Ubiquitin-Protein Ligases

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The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy.

Neurobiology of disease Aug 1, 2025
Refractory epilepsy is an intractable neurological disorder that can be associated with oligogenic/polygenic etiologies. Through trio-based whole-exome sequencing analysis, we identified a clinical case of refractory epilepsy with three candidate gen...
Male Disease Models, Animal Animals Ubiquitin-Protein Ligases Drosophila Drosophila Proteins Animals, Genetically Modified Female Humans GTPase-Activating Proteins Drug Resistant Epilepsy Low Density Lipoprotein Receptor-Related Protein-1
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[WW domain-containing ubiquitin E3 ligase 1 regulates immune infiltration in tumor microenvironment of ovarian cancer].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University May 20, 2025
OBJECTIVES: To explore the association of the expression of WW domain-containing ubiquitin E3 ligase 1 (WWP1) with immune infiltration in tumor microenvironment (TME) of ovarian cancer.
Cell Line, Tumor Mice Animals Ovarian Neoplasms Ubiquitin-Protein Ligases Mice, Nude Prognosis Gene Expression Regulation, Neoplastic Humans Tumor Microenvironment Female
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ET-PROTACs: modeling ternary complex interactions using cross-modal learning and ternary attention for accurate PROTAC-induced degradation prediction.

Briefings in bioinformatics Nov 22, 2024
MOTIVATION: Accurately predicting the degradation capabilities of proteolysis-targeting chimeras (PROTACs) for given target proteins and E3 ligases is important for PROTAC design. The distinctive ternary structure of PROTACs presents a challenge to t...
Proteolysis Targeting Chimera Proteolysis Proteins Ubiquitin-Protein Ligases Neural Networks, Computer Humans
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Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Nucleic acids research Dec 1, 2017
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety...
Cell Line Epigenesis, Genetic High-Throughput Nucleotide Sequencing Humans Embryonic Stem Cells Cell Differentiation Alternative Splicing Machine Learning Ubiquitin-Protein Ligases Tumor Suppressor Proteins Histone Code Cell Lineage Sequence Analysis, RNA Neural Networks, Computer
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[Apple polyphenol inhibited the proliferation and migration of breast cancer cell MDA-MB-231 mediated by UHRF1].

Wei sheng yan jiu = Journal of hygiene research Nov 1, 2017
OBJECTIVE: To investigate the effects of apple polyphenol on cell proliferation and migration of breast cancer cell line MDA-MB-231, and explore the potential mechanism.
Tannins Cell Line, Tumor Female Chlorogenic Acid Cell Movement Ubiquitin-Protein Ligases Humans Breast Neoplasms Flavonoids Cell Proliferation CCAAT-Enhancer-Binding Proteins Malus
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