AIMC Topic: Zebrafish
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Introduction to the Theme "Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care".
Annual review of pharmacology and toxicology
Oct 21, 2022
Investigations in pharmacology and toxicology range from molecular studies to clinical care. Studies in basic and clinical pharmacology and in preclinical and clinical toxicology are all essential in bringing new knowledge and new drugs into clinical...
Deep learning of cross-species single-cell landscapes identifies conserved regulatory programs underlying cell types.
Nature genetics
Oct 13, 2022
Despite extensive efforts to generate and analyze reference genomes, genetic models to predict gene regulation and cell fate decisions are lacking for most species. Here, we generated whole-body single-cell transcriptomic landscapes of zebrafish, Dro...
Thyroid endocrine disruption and hepatotoxicity induced by bisphenol AF: Integrated zebrafish embryotoxicity test and deep learning.
The Science of the total environment
Feb 4, 2022
Bisphenol AF (BPAF) is an emerging contaminant prevalent in the environment as one of main substitutes of bisphenol A (BPA). It was found that BPAF exhibited estrogenic effects in zebrafish larvae in our previous study, while little is known about it...
A novel deep learning-based 3D cell segmentation framework for future image-based disease detection.
Scientific reports
Jan 10, 2022
Cell segmentation plays a crucial role in understanding, diagnosing, and treating diseases. Despite the recent success of deep learning-based cell segmentation methods, it remains challenging to accurately segment densely packed cells in 3D cell memb...
Technologies bringing young Zebrafish from a niche field to the limelight.
SLAS technology
Jan 2, 2022
Fundamental life science and pharmaceutical research are continually striving to provide physiologically relevant context for their biological studies. Zebrafish present an opportunity for high-content screening (HCS) to bring a true in vivo model sy...
Object detection for automatic cancer cell counting in zebrafish xenografts.
PloS one
Nov 29, 2021
Cell counting is a frequent task in medical research studies. However, it is often performed manually; thus, it is time-consuming and prone to human error. Even so, cell counting automation can be challenging to achieve, especially when dealing with ...
Graphene oxide enhanced the endocrine disrupting effects of bisphenol A in adult male zebrafish: Integrated deep learning and metabolomics studies.
The Science of the total environment
Oct 29, 2021
In our previous studies, it was found that graphene oxide (GO) reduced the endocrine disruption of bisphenol A (BPA) in zebrafish embryo and larvae, but through different mechanisms. In this study, adult male zebrafish were selected to further unders...
Quantitative neuronal morphometry by supervised and unsupervised learning.
STAR protocols
Sep 30, 2021
We present a protocol to characterize the morphological properties of individual neurons reconstructed from microscopic imaging. We first describe a simple procedure to extract relevant morphological features from digital tracings of neural arbors. T...
A magnetically controlled soft miniature robotic fish with a flexible skeleton inspired by zebrafish.
Bioinspiration & biomimetics
Sep 27, 2021
The untethered miniature swimming robot actuation and control is difficult as the robot size becomes smaller, due to limitations of feasible miniaturized on-board components. Nature provides much inspiration for developing miniature robot. Here, a ne...
Exposure to polydopamine nanoparticles induces neurotoxicity in the developing zebrafish.
NanoImpact
Aug 30, 2021
Currently, the potential applications of polydopamine (PDA) nanoparticles in the biomedical field are being extensively studied, such as cell internalization, biocompatible surface modification, biological imaging, nano-drug delivery, cancer diagnosi...
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