Artificial Intelligence Medical Compendium

Policy learning from observational data is fundamental to applications ranging from personalized medicine to welfare-program targeting, but standard approaches optimize empirical performance and may fail when the deployment distribution differs from ... read more 

Language-guided video generation often captures scene content while missing the requested motion. We present ViMoLa (Video Motion Language), which predicts a motion prior from language and injects it into a frozen image-to-video backbone. A spatial v... read more 

Paleobotany has a 200-year problem: leaf fossils are often too poorly preserved to make proper taxonomic identification. Though they are the most abundant, and well-studied macroscopic fossil plant organ, many fossil leaves-- including specimens held... read more 

Protein models such as Evolutionary Scale Modeling (ESM), AlphaFold and Boltz have transformed computational protein science, yet a pretrained model rarely transfers to a particular laboratory's assay without adaptation to its data and experimental s... read more 

T cells are at the centre of adaptive immunity, protecting the organism against infection and cancer. T cell receptors (TCRs), expressed on the surface of T cells, enable the recognition of target cells through interactions with peptides presented by... read more 

Covalent chemoproteomics has become a powerful route to expanding the druggable proteome, enabling proteome-wide screening of compounds that covalently modify nucleophilic residues, most commonly cysteine. Yet typical experiments detect only 5-18% of... read more 

Genome foundation models hold great potential for advancing biological research, but modeling diverse complex genomes and generating controllable genome-scale sequences remain challenging. We present DeepD, a phylogeny-informed sparse mixture-of-expe... read more 

Enzyme catalyzed reactions drive metabolism and enable diverse applications in biotechnology and sustainable synthesis, but assigning catalytic functions to uncharacterized enzymes and finding enzymes for target reactions remain major challenges. Des... read more 

Cellular migration and tumor evolution are central to tissue homeostasis and cancer biology. Rapid advances in spatial genomics have raised the possibility of using somatic mutations to track these processes in situ in human tissues. However, frequen... read more 

Neural maturation in the "task-control" frontoparietal and dorsal attention networks is thought to support the development of adolescents' cognitive and adaptive functioning. Further, theory suggests that family and neighborhood contexts shape brain ... read more